師資陣容
專任教師-獸醫系
柯喬許 助理教授
助理教授
研究室
腫瘤免疫與藥理學研究室（獸三館301室）
研究領域
學、經歷
詳細內容
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歡迎獸醫系同學及研究生加入實驗室
學術發表
| 序 | 性質 | 篇名/作者 |
|---|---|---|
| 1. | 期刊論文 | Ke C.H., C.E. Wu, F. Lin and W.Y. Yang. 2025. Differential gene expression in Clostridium perfringens during pre-and post-infection phases and in jejunal tissues of broilers with necrotic enteritis induced by Clostridium perfringens alone and its coinfection with Eimeria. Poult. Sci. 104(2):104682. doi: 10.1016/j.psj.2024.104682 (SCI) |
| 2. | 期刊論文 | Ke C.H., M.E. Huang, H.Y. Wu, C.W. Yu, S.L. Lin, S.P. Lin, S.H. Yu, C.H. Huang and C.S. Lin. 2025. High-selective HDAC6 inhibitor alleviates bone marrow fibrosis through inhibiting collagen formation and extracellular matrix deposition. Sci. Rep. 15:28105. doi:10.1038/s41598-025-08384-6 (SCI) |
| 3. | 研討會論文 | C.-H. Ke, C.-H. Huang. Evaluating the efficacy of different bacterial cell wall materials and their particle sizes on vaccine adjuvants. Japan-Taiwan Joint Symposium for Innovations in Biomaterial & Device Design: From Research to Market. Poineer International Research Building. Taipei Tech, Taiwan. Mar 23 – 24, 2025. (Oral presentation) |
| 4. | 研討會論文 | C.-H. Ke, C.-S. Lin, K.-M. Sio, Y.-S. Wang. Development of a surface acoustic wave (SAW) biosensor for DR-70 detection as a diagnostic tool for canine malignancies. Veterinary Cancer Society Annual Conference. Salt Lake City, UT, USA. Sep 25 – 27. 2025. |
| 5. | 期刊論文 | C.-H. Ke, C.-E. Wu, F. Lin, W.-Y. Yang. 2025 February. Differential gene expression in Clostridium perfringens during pre-and post-infection phases and in jejunal tissues of broilers with necrotic enteritis induced by Clostridium perfringens alone and its coinfection with Eimeria. Poultry Science. 104(2):104682. |
| 6. | 期刊論文 | H.-J. Chang, C.-H. Ke, Y.-S. Wang, Y.-C. Kuo. 2025 March. Case report: effective management of residual glioblastoma with combined modality therapy. Frontiers in Oncology. 15:1451408. |
| 7. | 期刊論文 | C.-H. Ke, M.-E. Huang, H.-Y. Wu, C.-W. Yu, S.-L. Lin, S.-P. Lin, S.-H. Yu, C.-H. Huang, C.-S. Lin. 2025 August. High-selective HDAC6 inhibitor alleviates bone marrow fibrosis following the inhibition of collagen formation and extracellular matrix deposition. Scientific Reports. 15:28105. |
| 8. | 研討會論文 | C.-H. Ke, C.-S. Lin. Clinical outcomes, immunophenotypes, and prognostic factors in canine lymphoma diagnosed in Taiwan from 2013 to 2021. 2024 World Veterinary Cancer Congress, Tokyo, Japan. Mar 21 – 24, 2024. |
| 9. | 研討會論文 | C.-H. Ke, C.-S. Lin, C.-H. Hu, H.-C. Chiang, C.-L. Cheng, Y.-S. Wang. Xenograft cancer vaccination results in a prolonged disease-free interval in dogs with oral malignant melanoma. 2024 World Veterinary Cancer Congress, Tokyo, Japan. Mar 21 – 24, 2024. |
| 10. | 研討會論文 | C.-H. Ke, C.-S. Lin, K.-M. Sio, C.-H. Hu, C.-H. Huang, Y.-S. Wang. Increased disease-free survival in dogs with oral malignant melanoma receiving CEA-CAR-NK-92 MI cell therapies. 2024 American College of Veterinary Internal Medicine (ACVIM) Forum, Minneapolis, Minnesota, USA. Jun 6 – 8, 2024. |
| 11. | 研討會論文 | K.-M. Sio, C.-H. Ke, C.-S. Lin, Y.-S. Wang. Evaluating the efficacy of fibrinogen-fibrin degradation products (DR-70) as a biomarker for monitoring canine oral malignant melanoma progression and response to CEA-CAR NK cell therapy. The UTokyo-NTU Joint Conference, University of Tokyo, Japan. Dec 5, 2024. |
| 12. | 期刊論文 | C.-H. Ke, C.-N. Lin, C.-S. Lin. Hormone, targeted, and combinational therapies for breast cancers: from humans to dogs. 2024 January. International Journal of Molecular Sciences. 25(2): 732. |
| 13. | 期刊論文 | C.-H. Ke, M.-Y. Du, C. Chen, W.-J. Hsieh, C.-C. Lin, J. M. Ting, M.-T. Chiou, C.-N. Lin. 2024 March. Implementation of point-of-care platforms for rapid detection of porcine circovirus type 2. Journal of Veterinary Science. 25(2): e28. |
| 14. | 期刊論文 | C.-H. Ke, P.-Y. Lai, F.-Y. Hsu, P.-R. Hsueh, M.-T. Chiou, C.-N. Lin. 2024 April. Antimicrobial susceptibility and resistome of Actinobacillus pleuropneumoniae in Taiwan: a next-generation sequencing analysis. Veterinary Quarterly. 44(1):1-13. |
| 15. | 期刊論文 | C.-H. Ke, H.-Y. Wu, Y.-S. Wang, W.-H. Huang, C.-S. Lin. 2024 April. Tumors established in a defective immune environment reprogram the oncogenic signaling pathways to escalate tumor antigenicity. Biomedicines. 12(4): 846. |
| 16. | 期刊論文 | C.-H. Ke, C.-S. Lin, K.-M. Sio, C.-H. Wu, Y.-Y. Xia, J.-J. Lee, C.-H. Hu, C.-C. Liu, B.-S. Liaw, C.-L. Cheng, K.-H. Lin, Y.-S. Wang. 2024 July. DR-70 (fibrinogen-fibrin degradation products) as a prognostic biomarker in dogs with neoplasms. Veterinary Quarterly. 44(1):1-10. |
| 17. | 期刊論文 | Y.-Y. Xia, A.-T. Liao, R.-M. Liu, S.-Y. Yang, C.-C. Kuo, C.-H. Ke, C.-S. Lin, J.-J. Lee. 2024 August. Immunotherapeutic allogeneic dendritic cell and autologous tumor cell fusion vaccine alone or combined with radiotherapy in canine oral malignant melanoma is safe and potentially effective. Frontiers in Veterinary Science. 11:1397518. |
| 18. | 期刊論文 | H.-J. Chang, C.-H. Ke, Y.-S. Wang. 2024 October. Case report: combinations of immune checkpoint inhibitor, chemotherapy, and hyperthermia therapy avoid lymphatic recurrence in cholangiocarcinoma. Frontiers in Oncology. 14:1421340. |
| 19. | 期刊論文 | D. Nammuang, Y.-W. Shen, C.-H. Ke, N.-L. Kuan, K.-S. Yeh, Y.-C. Chang, C.-N. Lin, C.-Y. Chang, H.-W. Chang. 2024 October. Isolation and evaluation of the pathogenicity of a hybrid shiga toxin-producing and Enterotoxigenic Escherichia coli in pigs. BMC Veterinary Research. 24(1):480. |
| 20. | 期刊論文 | C.-H. Ke, J.-W. Chen, C.-S. Lin. 2024 December. Surveillance of drug residue profiles in Gallus gallus domesticus (silkie chicken) in Taiwan. Animals. 14(23):3529. |
| 21. | 研討會論文 | C.-H. Ke, C.-S. Lin. Kynurenine 3-monooxygenase and ki67 Are Effective Biomarkers for Canine Cancer Diagnosis. 2023 American College of Veterinary Internal Medicine (ACVIM) Forum, Philadelphia, Pennsylvania, USA. Jun 15 – 17, 2023. (Oral presentation) |
| 22. | 期刊論文 | C.-H. Ke, C.-C. Liu, S.-L. Wang, C.-S. Lin. 2023 March. Paired analysis of D-dimer and its correlated hemostatic parameters in 30 dogs with neoplasms after tumorectomy. Animals. 13(6): 969. |
| 23. | 期刊論文 | C.-H. Ke, K.-M. Sio, C.-H. Wu, Y.-Y. Xia, J.-J. Lee, C.-H. Hu, C.-C. Liu, C.-L. Lu, C.-L. Cheng, K.-H. Lin, H. Tomiyasu, Y.-S. Wang, C.-S. Lin. 2023 October. Increased DR-70 (fibrinogen-fibrin degradation products) concentrations as a diagnostic biomarker in dogs with neoplasms. Journal of Veterinary Internal Medicine. 37(6):2391–2401. |
| 24. | 期刊論文 | H.-P. Weng†, C.-H. Ke†, C.-W. Tung, A. Tani, C.-C. Wang, W.-Y. Yang, Y.-S. Wang, W. Han, C.-H. Liao, H. Tomiyasu, C.-S. Lin. 2023 October. Canine Diffuse Large B-cell Lymphoma Downregulates the Activity of CD8+ T-cells through Tumor-derived Extracellular Vesicles. Cancer Cell International. 23:252. (†, Equal first author) |
| 25. | 研討會論文 | C.-H. Ke, C.-S. Lin. Tumors Developed in Immunodeficient Hosts Associated with a Favorable Microenvironment to Facilitate Tumor Malignancy and Increase Tumor Immunogenicity. The 1st NTU-KU Bilateral Symposium (Animal Products Processing and Production Medicine), Department of Veterinary Medicine, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan. Jun 16 – 17, 2022. (Oral presentation) |
| 26. | 研討會論文 | C.-H. Ke, Y.-S. Wang, K.-M. Sio, C.-S. Lin. Fibrinogen Degradation Products as a Clinical Biomarker for Cancer Diagnosis and Prognosis in Neoplastic Dogs. 2022 American College of Veterinary Internal Medicine (ACVIM) Forum, Austin, Texas, USA. Jun 23 – 25, 2022. |
| 27. | 研討會論文 | C.-H. Ke, C.-S. Lin. Tumors developing within immunodeficient microenvironment reprogram the antigen profiles to serve as the potential anti-cancer strategy. The 7th UTokyo-NTU Joint Conference, Department of Veterinary Medicine, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan. Dec 7 – 9, 2022. (Oral presentation) |
| 28. | 研討會論文 | C.-C. Lee, C.-H. Ke, W.-H. Huang, C.-S. Lin. Development of diagnostic tools in feline lymphoma determined by histopathology, immunohistochemistry, and polymerase chain reaction for antigen receptor rearrangement. 2022 Autumn Conference, Chinese Society of Veterinary Science, National Taiwan University, Taipei, Taiwan. Dec 10, 2022. |
| 29. | 研討會論文 | K.-M. Sio, C.-H. Ke, C.-S. Lin. Elevated Plasma Kynurenine 3-monooxygenase (KMO) and Fibrinogen-Fibrin Degradation Products (DR-70) Concentrations in Canine Cancer Patients. 2022 Autumn Conference, Chinese Society of Veterinary Science, National Taiwan University, Taipei, Taiwan. Dec 10, 2022. |
| 30. | 研討會論文 | M.-E. Huang, C.-H. Ke, C.-S. Lin. Investigating the Potential Therapeutic Effects and Mechanisms of Novel Histone Deacetylases Inhibitors (HDACi) for Myelofibrosis. 2022 Autumn Conference, Chinese Society of Veterinary Science, National Taiwan University, Taipei, Taiwan. Dec 10, 2022. |
| 31. | 研討會論文 | C. Liang, C.-H. Ke, C.-S. Lin. The first cross-section study on co-infection of Cryptosporidium and Giardia spp. in Taiwan: an epidemiological assessment in companion animals. 2022 Autumn Conference, Chinese Society of Veterinary Science, National Taiwan University, Taipei, Taiwan. Dec 10, 2022. |
| 32. | 期刊論文 | C.-H. Ke, H. Tomiyasu, Y.-L. Lin, W.-H. Huang, H.-H. Huang, H.-C. Chiang, C.-S. Lin. 2022 January. Canine transmissible venereal tumour established in immunodeficient mice reprograms the gene expression profiles associated with a favourable tumour microenvironment to enable cancer malignancy. BMC Veterinary Research. 18(1):4. |
| 33. | 期刊論文 | C.-H. Ke, Y.-S. Wang, H.-C. Chiang, H.-Y. Wu, W.-J. Liu, C.-C. Huang, Y.-C. Huang, C.-S. Lin. 2022 February. Xenograft cancer vaccines prepared from immunodeficient mice increase tumor antigen diversity and host T cell efficiency against colorectal cancers. Cancer Letters. 526: 66-75. |
| 34. | 期刊論文 | C.-H. Ke, K.-M. Sio, S.-L. Wang, Y. Kuo, W.-H. Huang, C.-S. Lin. 2022 February. The high expression of legumain in canine neoplasms: a retrospective analysis of 100 cases. Animals. 12(4): 504. |
| 35. | 期刊論文 | T.-H. Huang, C.-H. Ke, C.-C. Chen, C.-H. Chuang, K.-W. Liao, Y.-H. Shiao, C.-S. Lin. 2022 April. The effects of freshwater clam (Corbicula fluminea) extract on serum tumor necrosis factor-alpha (TNF-α) in prediabetic patients in Taiwan. Marine Drugs. 20(4): 261. |
| 36. | 期刊論文 | C.-H. Ke†, Y.-H. Chiu†, K.-C. Huang, C.-S. Lin. 2022 December. Exposure of immunogenic tumor antigens in surrendered immunity and the significance of autologous tumor cell-based vaccination in precision medicine. International Journal of Molecular Sciences. 24(1): 147. (†, Equal first author) |
| 37. | 研討會論文 | C.-H. Ke, C.-S. Lin. Novel Cancer Vaccine with Induced Antigen Diversity Improves Antitumor Efficacy. 2021 Spring Conference, Chinese Society of Veterinary Science, National Chung Hsing University, Taichung, Taiwan. May 22, 2021. (Oral presentation) |
| 38. | 研討會論文 | C.-H. Ke, Y.-S. Wang, K.-M. Sio, S.-C. Chi, C.-S. Lin. Elevated plasma DR-70 (fibrinogen‐fibrin degradation products) levels as a diagnostic biomarker in neoplastic dogs. 2021 Autumn Conference, Chinese Society of Veterinary Science, National Chung Hsing University, Taichung, Taiwan. Dec 4, 2021. |
| 39. | 研討會論文 | C.-H. Ke, M.-E. Huang, W.-H. Huang, C.-S. Lin. Overexpression of Legumain in Neoplastic Canine Tissues: A Potential Biomarker in Dogs with Tumors. 2021 Autumn Conference, Chinese Society of Veterinary Science, National Chung Hsing University, Taichung, Taiwan. Dec 4, 2021. |
| 40. | 研討會論文 | S.-C. Chi, C.-H. Ke, C.-S. Lin. Investigating the Cryptosporidium and Giardia spp. infection in Taiwan: a cross-section analysis of 396 animals. The 6th UTokyo-NTU Joint Conference, Department of Veterinary Medicine, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan. Dec 10, 2021. |
| 41. | 研討會論文 | C.-H. Ke, C.-S. Lin. Autologous cancer vaccines produced from the immunocompromised hosts improve the antigen diversity and trigger robust Th-1 immune responses against colorectal cancers. The 6th UTokyo-NTU Joint Conference, Department of Veterinary Medicine, College of Bioresources and Agriculture, National Taiwan University, Taipei, Taiwan. Dec 10, 2021. (Oral presentation) |
| 42. | 研討會論文 | C.-H. Ke, H. Tomiyasu, C.-S. Lin. Xenotransplantation of canine transmissible venereal tumors alters the gene expression signatures and facilitates tumor progression. The Conference of Agricultural Science, Department of Life Sciences, Ministry of Science and Technology, Taichung Xinwuri Convention Center, Taichung, Taiwan. Dec 13, 2021. |
| 43. | 研討會論文 | C.-H. Ke, C.-S. Lin. Diversifying the tumor antigens and improving the treatment efficacy of autologous cancer vaccines: xenograft tumors developed in the immunodeficient hosts. The Conference of Agricultural Science, Department of Life Sciences, Ministry of Science and Technology, Taichung Xinwuri Convention Center, Taichung, Taiwan. Dec 13, 2021. |
| 44. | 期刊論文 | C.-T. Chen, C.-H. Ke, H.-P. Weng, C.-H. Liao, C.-S. Lin. 2021 March. Downregulation of Kynurenine 3-Monooxygenase inhibits cancer stemness-related genes in both human and canine breast tumor cell lines. Thai Journal of Veterinary Medicine. 51(2):347-355. |
| 45. | 期刊論文 | C.-H. Ke, C.-H. Hsu, Y.-L. Lin, W.-H. Huang, H.-P. Weng, Y.-T. Ke, C.-S. Lin. 2021 May. Curcumin and freshwater clam extracts alleviate the progression of osteoarthritis by reducing synovial inflammation and allowing cartilage regeneration. Processes. 9(6):931. |
| 46. | 期刊論文 | Y.-W. Tsang, C.-H. Liao, C.-H. Ke, C.-W. Tu, C.-S. Lin. 2021 September. Integrated molecular characterization to reveal the association between kynurenine 3-monooxygenase expression and tumorigenesis in human breast cancers. Journal of Personalized Medicine. 11(10): 948. |
| 47. | 期刊論文 | I-M. Kuo, J.-J. Lee, Y.-S. Wang, H.-C. Chiang, C.-C. Huang, P.-J. Hsieh, W. Han, C.-H. Ke, A. T Liao, C.-S. Lin. 2020 June. Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia. BMC Cancer. 20(1):603. |
| 48. | 研討會論文 | C.-H. Ke, H.-P. Weng, W.-H. Huang, C.-S. Lin. The Effects of Curcumin and Clam Extracts on Alleviating the Progression of Osteoarthritis. The 4th UTokyo-NTU Joint Conference, The University of Tokyo, Tokyo, Japan. Dec 9 – 10, 2019. |