Lab of Molecular Bacteriology

Salmonella is a pathogenic agent of public health concern. Fimbriae arehair-like appendages present on the outer membrane of many Enterobacteriaceae including Salmonella. This structure is implicated in theadherent event which is a prerequisite for bacterial colonization and may eventually results in infection. Salmonella possesses a variety of fimbrial gene cluster while the fim gene cluster is responsible for the production of type 1 fimbriae. One of the long term research goals of my lab is to understand the detail regulatory mechanism of type 1 fimbriae, the most commonly found fimbrial type of Salmonella, and to elucidate how type 1 fimbriae may involve in the infectious cycle of Salmonella. Production of extended-spectrum beta-lactamases (ESBL) confers resistance tothe commonly used beta-lactam drugs. The ESBLs reported thus far have been primarily documented in human clinical cases; nevertheless, attention has been drawn to non-human sources, such as animals, as possible origins of the infections. Another research interest in my lab is to characterize the ESBL-producing bacteria isolated from animals.
Faculty

Dr. Kuang-Sheng Yeh ksyeh@ntu.edu.twT. +886 2 33661289
Research interests

  1. Regulation of type 1 fimbriae in Salmonella enterica species
  2. Characterization of ESBL-producing microorganisms isolated from animals

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