Assistant Professor Hui-Wen Chang

Highest Degree: Ph.D. National Taiwan University
Employment History:
2014 August-2015 Jan: Assistant Research Scholar; Full-time, Graduated Institute of Molecular and Comparative Pathology, School of Veterinary Medicine, National Taiwan University. (Granted by Ministry of Science and Technology.)
2012 April-2014 March: Postdoctoral fellow; Full-time, Barouch Lab, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School.
2006 Nov-2011 Dec: Postdoctoral research; Full-time, Virology Division, Department of Infectious Diseases & Immunology, Veterinary Faculty, Utrecht University.

Research areas: Molecular pathogenesis of viral disease; subunit vaccine, inactive vaccine, and live attenuate vaccine development; molecular virology: viral virulent gene determination, cellular receptor identification, and virus-host interactions.
Tel+886-2-3366-9899 (office)
Email: huiwenchang@ntu.edu.tw
Office hours: By appointment


Publications :

  1. Chiou HY, Huang YL, Deng MC, Chang CY, Jeng CR, Tsai PS, Yang C, Pang VF, Chang HW (2015, Apr). Phylogenetic Analysis of the Spike (S) Gene of the New Variants of Porcine Epidemic Diarrhea Virus (PEDV) in Taiwan. Transboundary and Emerging Diseases 2015 Apr 22. doi: 10.1111/tbed.12357. . (IF: 2.944; ranking 1/133 veterinary science)
  2. Chiou HY, Yeh KS, Jeng CR, Chang HW, Chang LJ, Wu YH, Chan FT and Pang VF(2015). Disease surveillance in rescued and road-killed wild-ranging carnivores in Taiwan. Taiwan Veterinary Journal, Vol. 41, No. 2 (2015) 73–84.
  3. Chang HW, Tartaglia LJ, Whitney JB, Lim SY, Sanisetty S, Lavine CL, Seaman MS, Rademeyer C, Williamson C, Ellingson-Strouss K, Stamatatos L, Kublin J, Barouch DH. (2014, Dec). Generation and Evaluation of Clade C Simian-Human Immunodeficiency Virus Challenge Stocks.. Journal of Virology. (SCI, 7/33, Virology).
  4. Tsai YC, Jeng CR, Chang CC, Hsiao SH, Chang HW, Lin CM, Chia MY, Wan CH, Pang VF. 2014. Differences in the expression of innate immune response-modulating genes in blood monocytes between subclinically porcine circovirus type 2 (PCV2)-infected and PCV2-free pigs prior to and after lipopolysaccharide stimulation in vitro. Taiwan Vet J 40 (01): 37-48.
  5. Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. 2013. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature.2013 Oct 30. doi: 10.1038/nature12744. (IF: 42.351)
  6. Tsai YC*, Chang HW*, Jeng CR, Lin TL, Lin CM, Wan CH, Pang VF. The effect of infection order of porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus on dually infected swine alveolar macrophages.BMC Vet Res. 2012 Sep 25;8:174. doi: 10.1186/1746-6148-8-174. (*Equal contributors) (IF:1.861; ranking 18/143 veterinary science)
  7. Chang HW, Egberink HF, Halpin R, Spiro DJ, Rottier PJ. 2012. Spike protein fusion peptide and feline coronavirus virulence. Emerging Infectious Diseases Vol. 18, No. 7, July 2012. (IF:5.993; ranking 4/70 infectious disease)
  8. Chang HW, Egberink HF, Rottier PJ. 2011. Sequence analysis of feline coronaviruses and the circulating virulent/avirulent theory. Emerging Infectious Diseases Vol. 17, No. 4. (IF:6.169; ranking 5/70 infectious disease)
  9. Chia MY, Hsiao SH, Chan HT, Do YY, Huang PL, Chang HW, Tsai YC, Lin CM, Pang VF, Jeng CR. 2011. Evaluation of the immunogenicity of a transgenic tobacco plant expressing the recombinant fusion protein of GP5 of porcine reproductive and respiratory syndrome virus and B subunit of Escherichia coli heat-labile enterotoxin in pigs. Vet Immunol Immunopathol. 140:215-25. (IF:2.076; ranking 10/145 veterinary science)
  10. Chang HW, de Groot RJ, Egberink HF, Rottier PJ. 2010. Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene. J Gen Virol. 91:415-20. (IF: 3.568; ranking 11/33 virology)
  11. Chia MY, Hsiao SH, Chan HT, Do YY, Huang PL, Chang HW, Tsai YC, Lin CM, Pang VF, Jeng CR. 2010. The immunogenicity of DNA constructs co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus conjugated by GPGP linker in pigs. Vet Microbiol 146: 189-99. (IF: 3.256; ranking 3/145 veterinary science)
  12. Tsai YC, Jeng CR, Hsiao SH, Chang HW, Liu JJ, Chang CC, Lin CM, Chia MY, Pang VF. 2010.  Porcine circovirus type 2 (PCV2) induces cell proliferation, fusion, and chemokine expression in swine monocytic cells in vitro. Vet Res. 41:60 (IF:3.765; ranking 1/145 veterinary science)
  13. Chia MY, Hsiao SH, Chan HT, Do YY, Huang PL, Chang HW, Tsai YC, Lin CM, Pang VF, Jeng CR. 2010. Immunogenicity of recombinant GP5 protein of porcine reproductive and respiratory syndrome virus expressed in tobacco plant. Vet Immunol Immunopathol. 135(3-4):234-42. (IF: 2.176; ranking 13/145 veterinary science)
  14. Su BL, Chang HW, Lin CN, Pang VF, Chueh LL, Jeng CR. An update of aspects of feline immunodeficiency virus in Taiwan. Taiwan Vet J 35:167-173, 2009.
  15. Lin CM, Jeng CR, Chang HW, Guo IC, Huang YL, Tsai YC, Chia MY, Pang VF. 2008. Characterization of porcine circovirus type 2 (PCV2) infection in swine lymphocytes using mitogen-stimulated peripheral blood lymphocytes from healthy PCV2-carrier pigs. Vet Immunol Immunopathol. 124:355-66.  (IF: 1.907; ranking 12/135 veterinary science)
  16. Chang HW, Jeng CR, Lin CM, Liu JJ, Chang CC, Tsai YC, Chia MY, Pang VF. 2007. The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro. Vet Microbiol. 122:72-82. (IF: 2.01; ranking 7/133 veterinary science)
  17. Chang HW, Pang VF, Chen LJ, Chia MY, Tsai YC, Jeng CR. 2006. Bacterial lipopolysaccharide induces porcine circovirus type 2 replication in swine alveolar macrophages. Vet Microbiol. 115:311-9. (IF: 2.073; ranking 4/129 veterinary science)
  18. Chang HW, Jeng CR, Lin TL, Liu JJ, Chiou MT, Tsai YC, Chia MY, Jan TR, Pang VF. 2006. Immunopathological effects of porcine circovirus type 2 (PCV2) on swine alveolar macrophages by in vitro inoculation. Vet Immunol Immunopathol. 110:207-19. (IF: 1.994; ranking 8/129 veterinary science)
  19. Chang HW, Ho SY, Lo HF., Tu YC, Jeng CR, Liu CH, Wang FI, Pang VF. 2006. A vaccine-associated rhabdomyosarcoma with spinal epidural and pulmonary metastases in a cat. Vet Path 43: 55-8. (IF: 1.188; ranking 32/129 veterinary science)
  20. Chang HW, Jeng CR, Liu JJ, Lin TL, Chang CC, Chia MY, Tsai YC, Pang VF. 2005 . Reduction of porcine reproductive and respiratory syndrome virus (PRRSV) infection in swine alveolar macrophages by porcine circovirus 2 (PCV2)-induced interferon-alpha. Vet Microbiol 108:167-77.  (IF: 2.175; ranking 3/129 veterinary science)
  21. Lee YY, Chueh LL, Pang VF, Chang HW, Jeng CR. Detection of type 2 porcine circovirus by in situ hybridization. Taiwan Vet J 29(3):174-180.

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