Assistant Professor Hui-Wen Chen

Infection and Immunity Lab (Vet Building 1, R101/102)
Lab webpage: https://sites.google.com/site/winnichenlab/

Research field: Infectious disease epidemiology, Viral pathogenesis and immunity, Antivirals and vaccines, Virological diagnostics

Teaching: Veterinary virology, Veterinary immunology, Veterinary epidemiology, Poultry diseases, Biostatistics, Molecular and cellular biology, Viral pathogenesis and immunity

Tel: +886-2-3366-9450

Email: winnichen@ntu.edu.tw

陳慧文老師

Research articles:

  1. Chen HW, Wang CH. Characterization of hemagglutination activity of infectious bronchitis viruses in Taiwan. (under review). 2014.
  2. Cohen M, Zhang XQ, Senaati HP, Chen HW, Varki NM, Schooley RT, Gagneux P. Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase. Virology Journal 10:321-333, 2013. (SCI)
  3. Chen HW, King K, Tu J, Sanchez M, Luster AD, Shresta S. The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus. Journal of Immunology 191:4194-4201, 2013. (SCI)
  4. Chen HW, Cheng JX, Liu MT, King K, Peng JY, Zhang XQ, Wang CH, Shresta S, Schooley RT, Liu YT. Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses. Antiviral Research 99:371-382, 2013. (SCI)
  5. Wu NH, Tsai WT, Chen HW, Wang LC, Wang CH. Detection of anti-reticuloendotheliosis virus antibody by blocking enzyme-linked immunosorbent assay with expression envelope protein. Avian Diseases 57:71-75, 2013. (SCI)
  6. Huang YP, Chen HW, Wang CH. Review: Worldwide epidemiology of infectious bronchitis virus variants. Taiwan Veterinary Journal 38:258-269, 2012.
  7. Hong HW, Cheng IC, Chen HW, Wang CH. Comparison of NP and M primers for avian influenza virus detection by reverse transcription polymerase chain reaction. Taiwan Veterinary Journal 38:213-220, 2012.
  8. Chen HW, Wang CH, Cheng IC. A type-specific blocking ELISA for the detection of infectious bronchitis virus antibody. Journal of Virological Methods 173:7-12, 2011. (SCI)
  9. Hsu MF, Chen HW, Chen CF, Wang CH. The serologic prevalence of subgroup J avian leukosis virus in some chickens in Taiwan in 2010. Taiwan Veterinary Journal 37:227-223, 2011.
  10. Tsai WT, Chen ZF, Chen HW, Chang SW, Lee GG, Wang CH. Reticuloendotheliosis virus infection in Taiwan Country Chickens. Taiwan Veterinary Journal 37:278-283, 2011.
  11. Chen HW, Wang CH. A multiplex RT-PCR assay for the genotyping of avian infectious bronchitis viruses. Avian Diseases 54:104-108, 2010. (SCI)
  12. Chen HW, Huang YP, Wang CH. Identification of intertypic recombinant infectious bronchitis viruses from slaughtered chickens. Poultry Science 89:439-446, 2010. (SCI)
  13. Chen HW, Huang YP, Wang CH. Identification of Taiwan and China-like recombinant avian infectious bronchitis viruses in Taiwan. Virus Research 140:121-129, 2009. (SCI)

Conference presentation:

  1. Chen HW, Peng JY, Lee HC, He JL, Huang YP, Wang CH. Evolutionary changes in the receptor-binding site of the hemagglutinin protein in the avian influenza H6N1 virus may contribute to interspecies transmission. 2014. American Association of Avian Pathologists Meeting. Denver, CO. (Oral presentation)
  2. Chen HW, King K, Tu J, Sanchez M, Luster AD, Shresta S. The roles of IRF3 and IRF7 in innate antiviral immunity against dengue virus. 2013. American Society for Virology 32nd Annual Meeting. State College, PA. (Oral presentation)
  3. Chen HW, Wang CH. Characterization of hemagglutination activity of infectious bronchitis viruses and cell-associated hemadsorption activity of baculovirus expressed S1 glycoprotein. 2012. American Association of Avian Pathologists Meeting. San Diego, CA. (Oral presentation)
  4. Chen HW, Wang CH. Development of a type-specific blocking ELISA for the detection of infectious bronchitis virus antibody. 2010. American Association of Avian Pathologists Meeting. Atlanta, GA. (Oral presentation)
  5. Chen HW, Wang CH. A multiplex RT-PCR assay for the genotyping of avian infectious bronchitis viruses. 2009. American Society for Virology 28th Annual Meeting. Vancouver, Canada. (Poster presentation)
  6. Chen HW, Huang YP, Wang CH. Avian infectious bronchitis viruses identified in poultry slaughter houses exhibit wide genetic and antigenic varieties. 2009. 6th International Symposium on Avian Corona- and Pneumovirus and Complicating Pathogens. Rauischholzhausen, Germany. (Oral presentation)
  7. Chen HW, Wang CH. Characterization and application of monoclonal antibodies to avian infectious bronchitis virus. 2007. 15th Congress of the World Veterinary Poultry. Beijing, China. (Poster presentation)

Current research projects (funded by government agencies):

  1. Pathogenesis study and vaccine development of avian coronavirus variants
  2. Development of influenza H7N9 virus-like particles and recombinant viral proteins by baculoviral expression system for diagnostics and vaccines
  3. Development of an immunochromatographic strip test and a serotype-specific blocking ELISA for avian infectious bronchitis virus
  4. Molecular and serological epidemiology of H6N1 avian influenza virus in Taiwan
  5. Preparation and characterization of monoclonal antibodies against infectious bronchitis virus

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