Professor Fang-Chia Chang

Highest Degree: Ph.D. University of Texas Medical Branch
Research areas: Neuroscience, Sleep Neurophysiology, Sleep Medicine
Tel:+886-2-3366-3883 (office); +886-2-3366-3994 (lab)
Office hours: Monday 8:00-12:00, Friday 8:00-12:00 (by appointment)


  1. Yi, P.L., Lu, C.Y., Jou, S.B., Chang, F.C.*, 2015. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. J Biomed Sci 22, 49. (SCI)
  2. Chen, W. T., Chang, F.C., Chen, Y.J., Lin, J.G., 2014. An evaluation of electroacupuncture at the Weizhong acupoint (BL-40) as a means of relieving pain induced by extracorporeal shock wave lithotripsy. Evid Based Complement Alternat 2014, Article ID592319. (SCI)
  3. Yi, P.L., Lu, C.Y., Cheng, C.H., Tsai, Y.F., Lin, C.T., Chang, F.C.*, 2013. Amygdala opioid receptors mediate the electroacupuncture-induced deterioration of sleep disruptions in epilepsy rats. J Biomed Sci20, 85. (SCI)
  4. Yi, P.L., Lu, C.Y., Cheng, C.H., Tsai, Y.F., Lin, C.T., Chang, F.C.*, 2013. Activation of Amygdala Opioid Receptors by Electroacupuncture of Feng-Chi (GB20) Acupoints Exacerbates Focal Epilepsy. BMC Complement Altern Med 13, 290. (SCI)
  5. Hsaio, Y.T., Yi, P.L., Cheng, C.H., Chang, F.C.*, 2013. Disruption of footshock-induced theta rhythms by stimulating median raphe nucleus reduces anxiety in rats. Behav Brain Res 247, 193-200. (SCI)
  6. Jou, S.B., Kuo, I.F., Yi, P.L., Chang, F.C.*, 2013. Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats. Seizure 22, 221-229. (SCI)
  7. Hsiao, Y.T., Cheng, C.H., Yi, P.L., Chang, F.C.*, 2013. GABAergic neurons in the median raphe nucleus (MRN) modulate footshock-induced rapid eye movement (REM) sleep disturbance in rats. Taiwan Vet J 39(1), 27-38.
  8. Yi, P.L., Chen, Y.J., Lin, C.T., Chang, F.C.*, 2012. Occurrence of Epilepsy at Different Zeitgeber Times Alters Sleep Homeostasis Differently in Rats. Sleep 35(12), 1651-1665. (SCI)
  9. Hsu, C.Y., Chang, F.C.*, Ng, H.Y., Kuo, C.C., Lee, Y.T., Lu, C.Y., Lee, C.T., 2012. Disrupted circadian rhythm in rats with nephrectomy-induced chronic kidney disease. Life Sci 91, 127-131. (SCI)
  10. Hsiao, Y.T., Jou, S.B., Yi, P.L., Chang, F.C.*, 2012. Activation of GABAergic pathway by hypocretin in the median raphe nucleus (MRN) mediates stress-induced theta rhythm in rats. Behav Brain Res233, 224-231. (SCI)
  11. Cheng, C.H., Yi, P.L., Chang, H.H., Chang, F.C.*, 2012. Morphology Alterations of Synapses in the Ventromedial Nucleus (VM) of Thalamus and Caudal Nucleus Tractus Solitarius (NTS) after 10 Hz Electroacupuncture in Rats. Taiwan Vet J38(2), 75-83.
  12. Hsiao, Y.T., Yi, P.L., Li, C.L., Chang, F.C.*, 2012. Effect of Cannabidiol on Sleep Disruption Induced by the Repeated Combination Tests consisting of Open Field and Elevated Plus-maze in Rats. Neuropharmacology 62, 373-384. (SCI)
  13. Cheng, C.H., Yi, P.L., Chang, H.H., Tsai, Y.F., Chang, F.C.*, 2012. Kappa-opioid Receptors in the Caudal Nucleus Tractus Solitarius (NTS) Mediate 100 Hz Electroacupuncture-induced Sleep Activities in Rats. Evid Based Complement Alternat 2012, Article ID715024. (SCI)
  14. Chang, F.C.*, 2011. Effects of traditional Chinese medicine in insomnia treatment: the possible physiological mechanisms. In: Leon V. Berhardt, editor. Advances in Medicine and Biology: Volume 22. Nova Science Publishers:New York, Chapter 3.
  15. Chang, H.H., Yi, P.L., Cheng, C.H., Lu, C.Y., Hsiao, Y.T., Tsai, Y.F., Li, C.L., Chang, F.C.*, 2011. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol 135, 359-368. (SCI)
  16. Cheng, C.H., Yi, P.L., Lin, J.G., Chang, F.C.*, 2011. Endogenous opiates in the nucleus tractus solitaries mediate electroacupuncture-induced sleep activities in rats. Evid Based Complement Alternat 2011, Article ID159209. (SCI)
  17. Cheng, C.H., Ku, Y.F., Hou, C.H., Yeh, L.S., Chang, F.C.*, 2011. Nerve re-innervations by an end-to-side neurorrhaphy of myocutaneous transplantation in rats. Taiwan Vet J 37(3), 143-151.
  18. Chang, H.H., Cheng, C.H., Yi, P.L., Lu, C.Y., Tsai, Y.F., Hsiao, Y.T., Chang, F.C.*, 2011. Biphasic Effects of Wogonin in the Regulation of Spontaneous Sleep. Taiwan Vet J37 (3), 180-190.
  19. Chen, J.H., Jan, T.R., Chang, F.C., Chou, C.C., 2011. Metabolism, neurotoxicity, and food safety influences of acrylamide. Taiwan Vet J37(1), 63-73.
  20. Lu, C.Y., Yi, P.L., Tsai, C.H., Cheng, C.H., Chang, H.H., Hsiao, Y.T., Chang, F.C.*, 2010. TNF-NF-kappa B signaling mediates excessive somnolence in hemiparkinsonian rats. Behav Brain Res 208, 484-496. (SCI)
  21. Chang, F.C.*, 2009. Minireview: canine insomnia. J Vet Clin Sci2(4), 100-107.
  22. Wey, S.P., Wu, H.Y., Chang, F.C., Jan, T.R., 2008. Methamphetamine and diazepam suppress antigen-specific cytokine expression and antibody production in ovalbumin-sensitized BALB/c mice. Toxicol Lett 181, 157-162. (SCI)
  23. Yi, P.L., Hsiao, Y.T., Tsai, C.H., Jan, T.R., Lu, C.Y., Chang, F.C.*. Serotonergic system in the central nucleus of amygdala mediates cannabidiol-induced sleep alteration. The Open Sleep J 1, 58-68.
  24. Lu, M,K., Shih, H.Z., Huang, K.J., Ziemann, U., Tsai, C.H., Chang, F.C.*, Chen, Y.C., Lin, Y.T., Huang, W.S., Lee, C.C., Liu, C.S., 2008. Movement-Related Cortical Potential in Patients with Machado-Joseph Disease. Clin Neurophysiol 119, 1010-1019. (SCI)
  25. Yi, P.L., Lin, C.P., Tsai, C.H., Lin, J.G., Chang, F.C.*, 2007. The involvement of serotonin receptors in suanzaorentang-induced sleep alteration. J Biomed Sci 14, 829-840. (SCI)
  26. Yi, P.L., Tsai, C.H., Lu, M.K., Liu, H.J., Chen, Y.C., Chang, F.C.*, 2007. Interleukin-1beta mediates sleep alteration in rats with rotenone-induced parkinsonism. Sleep 30(4), 413-425. (SCI)
  27. Yi, P.L., Tsai, C.H., Chen, Y.C., Chang, F.C.*, 2007. Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, -induced sleep alteration. J Biomed Sci 14, 258-297. (SCI)
  28. Lu, M.K., Chang, F.C., Yang, Y.W., Lin, Y.C., Lee, C.C., Tsai, C.H., 2006. Abnormal movement-related cortical potential in patients with subcortical heterotopia. Brain Develop 28, 560-565. (SCI)
  29. Yang, Y.W., Tsai, C.H., Chang, F.C., Lu, M.K., Chiu, P., 2006. Reversible Paraneoplastic Limbic Encephalitis Caused by a Benign Ovarian Teratoma: Report of a Case and Review of literatures. J Neuro-Oncol 80, 309-312. (SCI)
  30. Tsai, C.H., Chang, F.C., Huang, Y.T, Chen, R.S., Chen, C.C., Wu, T., Weng, Y.H., Lee, S.Z., Lee, Z.D., Lieu, C.Y., Chang, H.C., Lu, M.K., Lee, C.C., Lu, C.S., 2005. Pallidotomy effect on the central excitability in patients with severe Parkinson’s disease. Movement Disord 20(4), 463-470. (SCI)
  31. Yang, Y.W., Chang, F.C., Tsai, C.H., Wu, J.C., Lu, C.S., Kuo, C.C., Lu, M.K., Chen, W.L., Lee, C.C., 2005. Clinical and magnetic resonance imaging manifestations of Holmes Tremor. Acta Neurol Taiwan 14(1), 9-15. (SCI)
  32. Yi, P.L., Tsai, C.H., Lin, J.G., Liu, H.J., Chang, F.C.*, 2004. Effects of electroacupuncture of “Anmian” acupoints on sleep activities in rats: the implication of caudal nucleus tractus solitarius.J Biomed Sci 11, 579-590. (SCI)
  33. Yi, P.L., Tsai, C.H., Lu, M.K., Chen, Y.J., Yang, Y.W., Chang, F.C.*, 2004. The Effects of a Brief Light Pulse and Intracerebroventricular Injection on Sleep-Wake Activity in Rats. Mid-Taiwan J Med9(4), 211-218.
  34. Yi, P.L., Opp, M.R., Chang, F.C.*, 2004. Increase of corticotropin-releasing hormone (CRH) in the central nervous system mediates stressors-induced sleep alteration. Mid-Taiwan J Med 9(3), 80-86.
  35. Yi, P.L., Tsai, C.H., Lin, J.G., Lee, C.C., Chang, F.C.*, 2004. Kindling stimuli delivered at different times in the sleep-wake cycle. Sleep 27(2), 203-212. (SCI)
  36. Chang, F.C., Tsai, H.Y., Yu, M.C., Yi, P.L., Lin, J.G., 2004. Central serotonergic system mediates analgesic effect of electroacupuncture on Zusanli (ST36) acupoint. J Biomed Sci 11, 179-185. (SCI)
  37. Tsai, C.H., Chang, F.C, Su, Y.C., Tsai, F.J., Lu, M.K., Lee, C.C., Kuo, C.C., Yang, Y.W., Lu, C.S., 2004. Two novel mutations of the glycine receptor gene and electrophysiological manifestation in a family with autosomal recessive hereditary hypereklpexia. Neurology 63(5), 893-896. (SCI)
  38. Chang, F.C., Opp, M.R., 2004. A corticotropin-releasing hormone antisense oligodeoxynucleotide reduces spontaneous waking in the rats. Regul Pept  117(1), 43-52. (SCI)
  39. Tsai, P.C., Chang, F.C., Tsai, C.H., Jang, F.R., Shen, A.N., Huang, Y.T., Lai, S.C., Yeh, T.H., Lu, M.K., Lu, C.S., 2003. Focal hand myoclonus caused by a small hematoma underneath the cerebral motor cortex. Eur Neurol 50, 114-117. (SCI)
  40. Tsai, T.C., Wu, J.Y., Lee, C.C., Tsai, C.H., Tsai, F.J., Chang, F.C., Kuo, C.C., 2003. No association between the dopamine transproter gene polymorphism and sporadic Parkinson’s disease among Chinese in Taiwan.  Mid-Taiwan J Med 8(Suppl 2), S75-8.
  41. Chang, F.C., Opp, M.R., 2002. The role of corticotropin-releasing hormone (CRH) in stressor-induced alterations of sleep in the rat. Am J Physiol Regul Integr Comp Physiol 283, R400-R407. (SCI)
  42. Tsai, C.H., Lo, S.K., See, L.C., Chen, H.Z., Chen, R.S., Weng, Y.H., Chang, F.C., Lu, C.S., 2002. Environmental risk factors of young onset Parkinson’s disease: a case-control study. Clin Neurol Neurosurg 104, 328-333. (SCI)
  43. Chang, F.C.*, Opp, M.R., 2001. Corticotropin-releasing hormone (CRH) as a regulator of waking, Neurosci Biobehav Rev 25(5), 445-453. (SCI)
  44. Chang, F.C., Opp, M.R., 2000. IL-1 is a mediator of increases in slow wave sleep induced by CRH receptor blockade. Am J Physiol Regul Integr Comp Physiol 279, R793-R802. (SCI)
  45. Chang, F.C., Opp, M.R., 1999. Pituitary CRH receptor blockade reduces waking in the rat. Physiol Behav 67, 691-696. (SCI)
  46. Chang, F.C., Opp, M.R., 1998. Blockade of corticotropin-releasing hormone (CRH) receptors reduces spontaneous waking in the rat. Am J Physiol Regul Integr Comp Physiol 275, R793-R802. (SCI)
  47. Yi, P.L., Chang, F.C., Tsai, J.J., Hung, C.R., Gean, P.W., 1995. The involvement of metabotropic glutamate receptors in long-term depression of N-methyl-D-aspartate receptor-mediated synaptic potential in the rat hippocampus. Neurosci Lett 185, 207-210. (SCI)
  48. Gean, P.W., Chang, F.C., Yi, P.L., Lin, J.H., Tsai, J.J., 1995. Activation of metabotropic glutamate receptors in conjunction with postsynaptic depolarization triggers a long-term depression of the N-methyl-D-aspartate receptor-mediated synaptic potential in the rat hippocampus. J Biomed Sci 2, 166-173. (SCI)
  49. Gean, P.W., Chang, F.C., Huang, C.C., Lin, J.H., Way, L.J., 1993. Long-term enhancement of EPSP and NMDA receptor-mediated synaptic transmission in the amygdala. Brain Res Bull 31, 7-11. (SCI)
  50. Gean, P.W., Chang, F.C., Huang, C.R., 1993. Use-dependent modification of a slow NMDA receptor-mediated synaptic potential in rat amygdalar slices. J Neurosci Res 34, 635-641. (SCI)
  51. Gean, P.W., Chang, F.C., 1992. Pharmacological characterization of excitatory synaptic potentials in rat basolateral amygdaloid neurons. Synapse 11, 1-9. (SCI)
  52. Gean, P.W., Chang, F.C., 1991. Ketamine suppresses synchronized discharges in the disinhibited amygdala slice. Brain Res Bull 26, 923-927. (SCI)
  53. Gean, P.W., Chang, F.C., 1991. Bursting discharges in disinhibited amygdala slices: the role of excitatory amino acid receptors. Neuropharmacology 30, 797-803. (SCI)
  54. Gean, P.W., Chou, S.M., Chang, F.C., 1990. Epileptiform activity involved by 4-aminopyridine in rat amygdala neurons: the involvement of N-methyl-D-aspartate receptors. Eur J Pharmacol 184, 213-221. (SCI)


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