張家宜 助理教授

分子病毒與抗原結構研究室 (獸一館 301及302室)

研究領域:病毒致病機轉、蛋白抗原決定位分析、病毒in vitro及in vivo競爭模式、診斷試劑與動物疫苗研發

擔任課程:獸醫公共衛生學及實習、基礎組專題討論、臨床討論

聯絡電話:Office: (02)3366-1292

電子信箱:chiayichang@ntu.edu.tw

學經歷:國立臺灣大學獸醫學博士
家畜衛生試驗所豬瘟研究組副研究員
家畜衛生試驗所製劑研究組研究員兼組長
世界動物衛生組織(WOAH)豬瘟參考實驗室專家

Office hours: 請同學先以Email方式與老師約定時間(歡迎對病毒及疫苗研發領域有興趣之獸醫系同學及研究生加入實驗室)




近期學術著作:

  • Journal PUBLICATIONS*corresponding

  1. Huang, Y.L., Meyer, D.,Postel, A., Tsai, K.J., Liu, H.M., Yang, C.H., Huang, Y.C., Berkley, N., Deng, M.C., Wang, F.I., Becher, P., Crooke, H., *Chang, C.Y., 2021.Identification of a Common Conformational Epitope on the Glycoprotein E2 of Classical Swine Fever Virus and Border Disease Virus. Viruses 13, 1655.
  2. Yang, J.L., Chang, C.Y., Sheng,C.S., Wang, C.C., Wang, F.I., 2021.The Tip Region on VP2 Protein of Bluetongue Virus Contains Potential IL-4-Inducing Amino Acid Peptide Segments. Pathogens 10, 3.
  3. Huang, Y.L., Tsai, K.J., Deng, M.C., Liu, H.M., Huang, C.C., Wang, F.I., *Chang, C.Y., 2020.In Vivo Demonstration of the Superior Replication and Infectivity of Genotype 2.1 with Respect to Genotype 3.4 of Classical Swine Fever Virus by Dual Infections. Pathogens 9, 261.
  4. Wang, F.I., Chang, C.Y., 2020.Classical Swine Fever: A Truly Classical Swine Disease. Pathogens 9,745.
  5. Tsai, K.J., Deng, M.C., Wang, F.I., Tsai, S.H., Chang, C., *Chang, C.Y.,Huang,Y.L., 2020.Deletion in the S1 Region of Porcine Epidemic Diarrhea Virus Reduces the Virulence and Influences the Virus-Neutralizing Activity of the Antibody Induced. Viruses 12, 1378.
  6. Tsai, T.H., *Chang, C.Y., Wang, F.I., 2020.A Highly Conserved Epitope (RNNQIPQDF) of Porcineteschovirus Induced a Group-Specific Antiserum: A Bioinformatics-Predicted Model with Pan-PTV Potential. Viruses 12, 1225.
  7. Yang, J.L., Chang, C.Y., Yen, W.C.W., Yen, L.H.C., Wang, C.C., Wang, F.I., 2020.Type I hypersensitivity is induced in cattle PBMC during Bluetongue virus Taiwan isolate infection. Vet.Immunol.Immunopathol. 226, 110071.
  8. Huang, Y.L., Deng, M.C., Tsai, K.J., Liu, H.M., Huang, C.C., Wang, F.I., *Chang, C.Y., 2017. Competitive replication kinetics and pathogenicity in pigs co-infected with historical and newly invading classical swine fever viruses. Virus Res. 228, 39-45.
  9. Postel, A., Meyer, D., Cagatay, G.N., Feliziani, F., De Mia, G.M., Fischer, N., Grundhoff, A., Milićević, V., Deng, M.C., Chang, C.Y., Qiu, H.J., Sun, Y., Wendt, M., Becher, P., 2017. High Abundance and Genetic Variability of Atypical Porcine Pestivirus in Pigs from Europe and Asia. Emerg. Infect. Dis. 23, 2104-2107.
  10. Meyer, D., Fritsche, S., Luo, Y., Engemann, C., Blome, S., Beyerbach, M., Chang, C.Y., Qiu, H.J., Becher, P., Postel, A., 2017. The double-antigen ELISA concept for early detection of Erns-specific classical swine fever virus antibodies and application as an accompanying test for differentiation of infected from marker vaccinated animals. Transbound. Emerg. Dis. 64, 2013-2022.
  11. Chang,J.C., Tsai,K.J., Hsu,W.C., Tu, Y.C., Chuang,W.C., Chang,C.Y., Chang, S.W., Lin,T.E., Fang,K.Y., Chang,Y.F., Tsai,H.J, Lee, S.H. 2015. Rabies Virus Infection in Ferret Badgers (Melogalemoschatasubaurantiaca) in Taiwan: A Retrospective Study. J.Wildl. Dis. 51, 923-928.
  12. Chiou, H.Y., Huang, Y.L., Deng, M.C., Chang, C.Y., Jeng, C.R., Tsai, P.S., Yang, C., Pang, V.F., Chang, H.W., 2015.Phylogenetic Analysis of the Spike (S) Gene of the New Variants of Porcine Epidemic Diarrhoea Virus in Taiwan.Transbound. Emerg. Dis. 64, 157-166.
  13. Deng, M.C., Chang, C.Y., Huang, T.S., Tsai, H.J., Chang, C., Wang, F.I., Huang, Y.L., 2015.Molecular epidemiology of porcine reproductive and respiratory syndrome viruses isolated from 1991 to 2013 in Taiwan.Arch. Virol. 160,2709-2718.Sung, M.H., Deng, M.C., Chung, Y.H., Huang, Y.L., Chang, C.Y., Lan, Y.C., Chou, H.L., Chao, D.Y., 2015.Evolutionary characterization of the emerging porcine epidemic diarrhea virus worldwide and 2014 epidemic in Taiwan.Infect. Genet. Evol. 36,108-115.
  14. Wang, F.I., Deng, M.C., Huang, Y.L.,*Chang, C.Y., 2015. Structures and functions of pestivirus glycoproteins: not simply surface matters(Review). Viruses7, 3506-3529.
  15. Chang, C.Y., Deng, M.C., Wang, F.I., Tsai, H.J., Yang, C.H., Chang, C., Huang, Y.L., 2014. The application and development of duplicate reverse transcription real-time PCR for the surveillance of porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 in Taiwan. J.Virol. Method 201, 13-19.
  16. Chiu, S.C., Yang, C.L., Chen, Y.M., Hua, S.C., Chiu, K.C., Lin, Y.C., Chang, C.Y.,Wang, F.I., 2014. Multiple models of porcine teschovirus pathogenesis in endemically infected pigs. Vet. Microbiol. 168, 69-77.
  17. Deng, M.C., Chang, C.Y.,Huang, T.S., Kuo, S.T., Tsai, H.J., Chang, C., Huang, Y.L., 2014. The outbreak of porcine epidemic diarrhea in Taiwan. Taiwan Vet. J. 40, 115-121.
  18. Huang, Y.L., Deng, M.C., Wang, F.I., Huang, C.C., *Chang, C.Y., 2014. The challenges of classical swine fever control: modified live and E2 subunit vaccines (Review). Virus Res. 179, 1-11.
  19. Huang, Y.L., Pang, V.F., Deng, M.C., Chang, C.Y., Jeng, C.R., 2014. Porcine circovirus type 2 decreases the infection and replication of attenuated classical swine fever virus in porcine alveolar macrophages. Res. Vet. Sci. 96, 187-195.
  20. Lin, Y.L., Chang, C.Y., Pan, C.H., Deng, M.C., Tasi, H.J., Lee, F., 2014. First Finding of Southeast Asia Topotype of Foot-and-Mouth Disease Virus in Kinmen, Taiwan in the 2012 Outbreak. J. Vet. Med. Sci. 76, 1479-1485.
  21. Tung, Y.C., Chang, C.Y., Wang, F.I., 2014. The classical swine fever virus LPC vaccine and E2 glycoproteins protect from challenge with genotypically homologous viruses. Taiwan Vet. J. 40, 163-172.
  22. Chang, C.Y., Huang, C.C., Deng, M.C., Huang, Y.L., Lin, Y.J., Liu, H.M., Lin, Y.L., Wang, F.I., 2012.Identification of conformational epitopes and antigen-specific residues at the D/A domains and the extramembrane C-terminal region of E2 glycoprotein of classical swine fever virus. Virus Res. 168, 56-63.
  23. Chang, C.Y., Huang, C.C., Deng, M.C., Huang, Y.L., Lin, Y.J., Liu, H.M., Lin, Y.L., Wang, F.I., 2012. Antigenic mimicking with cysteine-based cyclized peptides reveals a previously unknown antigenic determinant on E2 glycoprotein of classical swine fever virus. Virus Res. 163, 190-196.
  24. Chiu, S.C., Hu, S.C., Chang, C.C., Chang, C.Y., Huang, C.C., Pang, V.F., Wang, F.I., 2012. The role of porcine teschovirus in causing diseases in endemically infected pigs.Vet.Microbiol. 161, 88-95.
  25. Huang, Y.L.,Pang, V.F., Deng, M.C., Chang, C.Y., Shih, C.N., Wan, C.H., Jeng, C.R., 2012. Reduction of classical swine fever virus-specific cell proliferative response of porcine peripheral blood mononuclear cells by porcine circovirus type 2. Taiwan Vet. J. 38, 164-176.
  26. Huang, Y.L., Pang, V.F., Lin, C.M., Tsai, Y.C., Chia, M.Y., Deng, M.C., Chang, C.Y., Jeng, C.R., 2011. Porcinecircovirustype2 (PCV2) infection decreases the efficacy of an attenuated classical swine fever virus (CSFV) vaccine. Vet. Res. 42, 115.
  27. Chang, C.Y., Huang, C.C., Lin, Y.J.,Deng, M.C., Tsai, C.H., Chang, W.M., Wang, F.I., 2010. Identification of antigen-specific residues on E2 glycoprotein of classical swine fever virus. Virus Res. 152, 65-72.
  28. Chang, C.Y., Huang, C.C., Lin, Y.J.,Deng, M.C., Chen, H.C., Tsai, C.H., Chang, W.M., Wang, F.I., 2010. Antigenic domains analysis of classical swine fever virus E2 glycoprotein by mutagenesis and conformation-dependent monoclonal antibodies. Virus Res. 149, 183-189.
  • BOOK CHAPTERS

  1. Wang, F.I., Chang, C.Y.,Huang, C.C., 2019. Togaviruses. In: Zimmerman J., Karriker L., Ramirez A., Schwartz K., Stevenson G., and Zhang J. (editors). Diseases of swine (11th edition). John Wiley & Sons, Hoboken, NJ, pp. 740-742.
  2. Wang, F.I., Chang, C.Y.,Huang, C.C., 2012. Togaviruses. In: Zimmerman J., Karriker L., Ramirez A., Schwartz K., and Stevenson G. (editors). Diseases of swine (10th edition). John Wiley & Sons, Ames, Iowa, pp. 644-646.
  • ORAL PRESENTATIONS(selected)

  1. Chang, C.Y., 2019. Surveillance, control and research of classical swine fever in Taiwan. The international symposium ofclassical swine fever. (Taiwan)
  2. Chang, C.Y., 2019. The African swine fever and classical swine fever surveillance in Taiwan and surrounded islands. The Asian Society of Conservation Medicine. (Cambodia)
  3. Chang, C.Y., 2015. The epidemiology and pathogenesis of novel porcine epidemic diarrhea virus in Taiwan. The 7th International Symposium on Emerging and Re-emerging Pig Disease. (Japan)
  4. Chang, C.Y.,Huang, C.C., Deng, M.C.,Huang, Y.L., Wang, F.I., 2012. Identification of conformational and antigen-specific epitopeson E2 glycoprotein of classical swine fever virus. 22nd international pig veterinary society (IPVS) congress. (South Korea)
  5. Chang, C.Y.,Lin, Y.J.,Tsai, H.J., 2012. Situation and prevention of FMD in Taiwan. Symposium on Prevention and Control of Foot and Mouth Disease. (South Korea)
  6. Chang, C.Y., Huang, C.C., Lin, Y.J.,Deng, M.C., Wang, F.I., 2010. Analysis of antigenicity among various subgroups of classical swine fever virus. 21st international pig veterinary society (IPVS) congress. (Canada)

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