吳乃慧 助理教授

3D培養暨禽病研究室 (獸三館 303室)

研究領域:3D培養系統、多重病原共同感染、禽病學、病毒學

擔任課程:禽病學、經濟動物診療實習

聯絡電話:Office:(02) 3366-3859; Lab:(02) 3366-3860

電子信箱:naihueiwu@ntu.edu.tw

學經歷:德國漢諾威獸醫大學(University of Veterinary Medicine Hannover)博士
德國漢諾威獸醫大學 病毒所 獸醫兼獨立博士後研究員
德國漢諾威獸醫大學 新興傳染病及人畜共通傳染病研究中心 獸醫兼獨立博士後研究員

Office hours: 請同學以Email方式與老師約定時間; 歡迎大三以上獸醫系同學及研究生加入實驗室




近期學術著作:

  • 期刊論文:

  1. Shin DL, Yang W, Peng JY, Sawatsky B, von Messling V, Herrler G, Wu NH*. Avian Influenza A Virus Infects Swine Airway Epithelial Cells without Prior Adaptation. Viruses 2020 May; 28;12(6):E589. (*corresponding) (SCI, IF: 3.816, ranking 12/37 Virology)
  2. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell 2020 Apr; 16;181(2):271-280 (SCI, IF: 38.637, ranking 1/297 Biochemistry & Molecular biology)
  3. Shin DL, Siebert U, Lakemeyer J, Grilo M, Pawliczka I, Wu NH, Valentin-Weigand P, Haas L, Herrler G. Highly Pathogenic Avian Influenza A(H5N8) Virus in Gray Seals, Baltic Sea Emerging Infectious Diseases 2019 Dec; 25(12):2295-2298 (SCI, IF: 7.185, ranking 5/89 Infectious diseases)
  4. Meng F, Tong J, Vötsch D, Peng JY, Cai X, Willenborg M, Herrler G*, Wu NH*, Valentin-Weigand P*. Viral co-infection replaces effects of suilysin on adherence and invasion of S. suis into respiratory epithelial cells grown under air-liquid interface conditions. Infect Immun. 2019 Jul;87. DOI: 10.1128/IAI.00350-19 (*corresponding) (IF:3.106, ranking 34/89 Infectious diseases)
  5. Fu Y, Dürrwald R, Meng F, Tong J, Wu NH, Su A, Yin X, Haas L, Schmidtke M, Zell R, Krumbholz A, Herrler G. Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence. J Infect Dis. 2019 Feb. 19;219(10):1596-1604. doi: 10.1093/infdis/jiy719. (IF:5.186, ranking 9/88 Infectious diseases)
  6. Tong J, Fu Y, Wu NH, Rohde M, Meng F, Valentin-Weigand P, Herrler G. Sialic acid-dependent interaction of group B streptococci with influenza virus-infected cells reveals a novel adherence and invasion mechanism. Cell Microbiol. 2018 Apr;20(4). doi: 10.1111/cmi.12818. (IF: 4.41, ranking 24/125 Microbiology)
  7. Yang W, Lambertz RLO, Punyadarsaniya D, Leist SR, Stech J, Schughart K, Herrler G, Wu NH*, Meng F*. Increased virulence of a PB2/HA mutant of an avian H9N2 influenza strain after three passages in porcine differentiated airway epithelial cells. Vet Microbiol. 2017 Nov;211:129-134. doi: 10.1016/j.vetmic.2017.10.015. (*corresponding) (IF: 2.524, ranking 8/140 Veterinary science)
  8. Wu NH, Yang W, Beineke A, Dijkman R, Matrosovich M, Baumgärtner W, Thiel V, Valentin-Weigand P, Meng F, Herrler G. The differentiated airway epithelium infected by influenza viruses maintains the barrier function despite a dramatic loss of ciliated cells. Scientific Reports. 2016 Dec 22;6:39668. doi: 10.1038/srep39668. (IF: 4.259, ranking 10/64 Multidisciplinary sciences)
  9. Meng F, Wu NH, Seitz M, Herrler G, Valentin-Weigand P. Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions. Scientific Reports. 2016 May 27;6:26748. doi: 10.1038/srep26748. (IF: 4.259, ranking 10/64 Multidisciplinary sciences)
  10. Wu NH, Meng F, Seitz M, Valentin-Weigand P, Herrler G. Sialic acid-dependent interactions between influenza viruses and Streptococcus suis affect the infection of porcine tracheal cells. J Gen Virol. 2015 Sep;96(9):2557-68. doi: 10.1099/jgv.0.000223.(IF:3.192, ranking 13/33 Virology)
  11. Meng F, Wu NH, Nerlich A, Herrler G, Valentin-Weigand P, Seitz M. Dynamic Virus-Bacterium Interactions in a Porcine Precision-Cut Lung Slice Coinfection Model: Swine Influenza Virus Paves the Way for Streptococcus suis Infection in a Two-Step Process. Infect Immun. 2015 Jul;83(7):2806-15. doi: 10.1128/IAI.00171-15. (IF:3.603, ranking 20/83 Infectious diseases)
  12. Wu NH, Tsai WT, Chen HW, Wang LC, Wang CH. Detection of anti-reticuloendotheliosis virus antibody by blocking enzyme-linked immunosorbent assay with expression envelope protein. Avian Diseases 57:71-75, 2013. (IF: 1.107, ranking 51/132 Veterinary science)

     

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