林翰佑 副教授

研究領域:水產動物疾病, 免疫學, 微生物學, 實驗動物學, 疫苗及診斷試劑設計

擔任課程:

聯絡電話:Office:; Lab:

電子信箱:hanyou@mail.ncku.edu.tw

學經歷:

1993-1998 國立台灣大學 獸醫學研究所 博士

1988-1993 國立台灣大學 獸醫學系 學士

2006-2016 國立成功大學 生物科技研究所 助理教授

2003- 國立成功大學 農業生物技術研究中心 助理研究員

1998-2003 中央研究院 生物農業科學研究所籌備處 博士後研究

2001 專門職業及技術人員高等考試及格 科目 : 獸醫師

1993 獸醫師檢覈考試及格

Office hours: 請同學先以Email方式與老師約定時間




林翰佑

近期學術著作:

    專利:

    1. US 6,777,247 Nervous necrosis virus protein ( 美國專利 , 效期 2004-2024, 已技轉 )
    2. 227114 水生動物用口服疫苗 ( 中華民國專利 , 效期 : 2005-2022, 已技轉 )
    3. US 6,872,386 Oral vaccines ( 美國專利 , 效期 : 2005-2025, 已技轉 )

    期刊論文:

    1. Hou, Chia Yi; Lin, John Han You; Lin, Shih Jie; Kuo, Wan Ching; Lin, Han Tso,2016,Down-regulation of CD53 expression in Epinephelus coioides under LPS, poly (I:C), and cytokine stimulation,Fish and Shellfish Immunology; 魚類與甲殼類免疫學,51,pp143-152 (SCI)
    2. Ho, Li Ping; Chang, Chin Jun; Liu, Hsiao Cheng; Yang, Huey Lang; Lin, John Han You,2014,魚類疾病期刊,Journal of Fish Disesase;,37,1,pp51-62 (SCI)
    3. Hsu, Yi Jiou; Hou, Chia Yi; Lin, Shih Jie; Kuo, Wan Ching; Lin, Han Tso; Lin, John Han You,2013,The biofunction of orange-spotted grouper (Epinephelus coioides) CC chemokine ligand 4 (CCL4) in innate and adaptive immunity,Fish and Shellfish immunology; 魚類與甲殼類免疫學,35,6,pp1891-1898 (SCI)
    4. Chen, H.H.; Lin, H.T.; Foung, Y.F.; Lin, J.H.Y,2012,The bioactivity of teleost IL-6: IL-6 protein in orange-spotted grouper (Epinephelus coioides) induces Th2 cell differentiation pathway and antibody production,Developmental and comparative immunology;,38,2,pp285-294 (SCI)
    5. Yeh, Y.C.; Lee, C.W.; Pan, Y.W.; Hsu, Y.J.; Hung, H.Y.; Chen, Y.M.; Lin, H.Y.; Chen, T.Y.; Yang, H.L.; Wang, H.C.,2012,Identification and characterization of DSCAM isoforms isolated from Orange-Spotted Grouper Epinephelus coioides,Developmental and comparative immunology;,38,1,pp148-159 (SCI)
    6. Chen, Tsung-Yuan; Lin, Han-You; Lin, Chin-Chiu; Lu, Chung-Kuan; Chen, Yi-Min,2012,Picochorum as an alternative to Nannochloropsis for grouper larval rearing,Aquaculture;,338-341,pp82-88 (SCI)
    7. Chen, Yi Min; Shih, Ching Hung; Liu, Hsiao Chien; Wu, Cheng Lung; Lin, Chin Chiu; Wang, Han Ching; Chen, Tzong Yueh; Yang, Huey Lang,2011,An oral nervous necrosis virus vaccine using Vibrio anguillarum as an expression host provides early protection,Aquaculture;, (SCI)
    8. Liu, Fu-Chien; Su, Chung-Ren; Wu, Tzi-Yi; Su, Shyh-Gang; Yang, Huey-Lang; Lin, Han-You; Wu, Tian-Shung,2011,Efficient (1)H-NMR quantitation and investigation of N-acetyl-D-glucosamine (GlcNAc) and N,N'-diacetylchitobiose (GlcNAc)(2) from chitin,International Journal of Molecular Sciences;,12,pp5828-5841 (SCI)
    9. Lam, Wai San; Wu, Szu Yin; Lin, Shih Jie; Lin, Chin Chiu; Chen, Yi Min; Wang, Han Ching; Chen, Tzong Yueh; Lin, Han Tso,2011,The expression of two novel orange-spotted grouper (Epinephelus coioides) TNF genes in peripheral blood leukocytes, various organs, and fish larvae,Fish and Shellfish Immunology;,30,pp618-629 (SCI)
    10. Ho, Li Ping; Lin, Han You; Liu, Hsiao Chien; Chen, Huey En; Chen, Tzong Yueh,2011,Identification of antigens for the development of a subunit vaccine against Photobacterium damselae ssp. piscicida,Fish and Shellfish Immunology;,30,pp412-419 (SCI)
    11. KC Han-Ching Wang; Chun-Wei Tseng; Han-You Lin; I-Tung Chen; Ya-Hui Chen; Yi-Min Chen; Tzong-Yueh Chen; Huey-Lang Yang,2010,RNAi knock-down of the Litopenaeus vannamei Toll gene (LvToll) significantly increases mortality and reduces bacterial clearance after challenge with Vibrio harveyi.,Developmental and comparative immunology;,34,1,pp49-58 (SCI)
    12. Chang C-C; Lin P-S; Hou M-Y; Lin C-C; Hung M-N; Wu T-M; Shu P-Y; Shin W-Y; Lin J H-Y; Chen W-C; Wu H-S; Lin L-J,2009,Identification of Risk Factors of Coxiella burnetii (Q fever) Infection in Veterinary-Associated Populations in Southern Taiwan.,Zoonoses and public health;, (SCI)
    13. Pin-Hsiang Chou; Hao-Shuo Chang; I.-Tung Chen; Han-You Lin; Yi-Min Chen; Huey-Lang Yang; K.C. Han-Ching Wang,2009,The putative invertebrate adaptive immune protein Litopenaeus vannamei Dscam (LvDscam) is the first reported Dscam to lack a transmembrane domain and cytoplasmic tail.,Developmental and comparative immunology;,33,12,pp1258-67 (SCI)
    14. John Han-You Lin; Han-Tso Lin; Carmen Lopez; Tzong-Yueh Chen; Ming-Shyan Chen; Huey-LangYang,2008,A Comparison of the Expression of immunity-related rag-1 and ikaros Genes with Histogenesis of the Thymus in Epinephelus malabaricus.,Aquaculture Research;,39,pp252-262 (SCI)
    15. Young-Mao Chen; Yung-Lin Su; Pei-Shiuan Shie; John Han-You Lin; Huey-Lang Yang; Tzong-Yueh Chen,2008,Grouper Mx confers resistance to nodavirus and interacts with coat protein.,Developmental and comparative immunology;,32,7,pp825-836 (SCI)
    16. *CC Lin; JHY Lin ; MS Chen ; HL Yang,2007, An oral Nervous Necrosis Virus vaccine that induces protective immunity in larvae of grouper ( Epinephelus coioides) ,Aquaculture,268,pp265-273 (SCI)
    17. *JHY Lin; TY Chen; MS Chen; HE Chen; RL; Chou; ZY Cheng; MS Su ; HL Yang,2006,Vaccination with three inactivated pathogens of cobia ( Rachycentron canadum ) stimulates protective immunity,Aquaculture,255,1-4,pp125-132 (SCI)
    18. *SP Chen; HL Yang; GM Her; HY Lin ; MF Jeng; JL Wu ; JR Hong,2006,Betanodavirus induces phosphatidylserine exposure and loss of mitochondrial membrane potential in secondary necrotic cells, both of which are blocked by bongkrekic acid ,Virology,347,pp379-391 (SCI)
    19. *YM Chen; YL Su; JHY Lin ; HL Yang ; TY Chen,2006,Cloning of an orange-spotted grouper (Epinephelus coioides) Mx cDNA and characterisation of its expression in response to nodavirus ,Fish and Shellfish Immunology,20,1,pp58-71 (SCI)
    20. *SP Chen; HL Yang; HY Lin ; MC Chen; JL Wu ; JR Hong,2006, Enhanced viability of a nervous necrosis virus-infected stable cell line over-expressing a fusion product of the zfBl-xL and green fluorescent protein genes,Journal of Fish Diseases,29,pp347-354 (SCI)
    21. *HT Lin; HY Lin ; HL Yang,2005, Histology and histochemical enzyme-staining patterns of major immune organs in Epinephelus malabaricus,Journal of Fish Biology,66,3,pp729-740 (SCI)
    22. JHY Lin ; CC Yu; CC Lin ; HL Yang,2005,An oral delivery system for recombinant subunit vaccine to fish.,Developments in biologicals;,121,pp175-180 (期刊論文)
    23. *PR Rajan; JHY Lin ; MS Ho ; Yang HL,2003, Simple and rapid detection of Photobacterium damselae subsp. piscida by a PCR technique and plating method,Journal of Applied Microbiology,95,pp1375-1380 (SCI)
    24.  

    研討會:

    1. *CH Shih; HC Liu; CL Wu; CC Lin; YM Chen; HY Lin ; HL Yang,2008, Vibrio expression system: a novel host for nervous necrosis virus subunit vaccine production,;,Taipei , Taiwan,
    2. HY Lin; YM Chen; PF Wu; JY Chen; HL Yang,2008, Development a gene-deleted subunit vaccine of Aeromonas hydrophila,World Aquaculture Symposium 2008;,Busan , Korea,
    3. Chen Y-M; Shie P-S; Yang H-L; Chen T-Y,2008,Roles of grouper Mx in regulation of cell cycle and resistance to nodavirus.,The 7th Symposium on Diseases in Asian Aquaculture.;,Taipei, Taiwan.,
    4. Chen Y-M; Shie H-P; Yang H-L; Chen T-Y,2008,Identification of small heat shock protein as stress-induced molecular chaperone-like activity in nodavirus infected grouper.,The 7th Symposium on Diseases in Asian Aquaculture.;,Taipei, Taiwan.,
    5. Tasi T-J; Lee S-S; Chen Y-M; Lee G-B,; Yang H-L; Chen T-Y,2008,One step multiplex diagnosis for grouper pathogens detection.,The 7th Symposium on Diseases in Asian Aquaculture.;,Taipei, Taiwan.,
    6. Chang C-W; Chen L-J; Su Y-C; Yang, H-L; Wu J-L; Hong J-R,2008,Identification of a novel antiapoptotic protein B1 encoded by the RGNNV TN1 strain in fish cells.,The 7th Symposium on Diseases in Asian Aquaculture.;,Taipei, Taiwan.,
    7. *HL Yang; CM Lu; CC Lin; MS Chen ; JHY Lin,2007,Improve Protection Against White Spot Syndrome Virus (WSSV) of Tiger Shrimp Penaeus monodon by Oral Administration of Artemia Encapsulation Inactivated Vibrio ,Stirling , Scotland,
    8. *HC Chuang; YM Chen; HY Lin ; HL Yang ; TY Chen,2006,Detection of Nerve Necrosis Virus by a Real-time PCR Method and Characterization of Its Tissue Distributions in Giant Grouper (Epinephelus lanceolatus), Hiroshima, Japan,
    9. *HL Yang; HY Lin ; CC Lin,2006,The development of an oral NNV vaccine and its efficacy evaluation in the larvae of Epinephelus coioides, Hiroshima , Japan,
    10. *HY Lin; YM Chen; MS Chen; CC Lin ; HL Yang,2006, Mornitoring nervous necrosis virus infection in a commercil grouper hatchery in Taiwan, Hiroshima,Japan,
    11. *CC Lin; MS Chen; HY Lin ; HL Yang,2006, Establishment of experimental challenge model of grouper ( Epinephelus coioides ) for NNV, Hiroshima,Japan,

     

    研究計畫:

    1. 石斑魚二腫瘤壞死因子α(TNF-α1/α2)在非特異性免疫反應所扮演角色之研究 [2015/08/01 ~ 2016/07/31]
    2. 石斑魚腫瘤壞死因子基因選殖與其在魚苗發展階段基因表現及功能性研究 [2010/08/01 ~ 2011/07/31]
    3. 石斑魚腫瘤壞死因子基因選殖與其在魚苗發展階段基因表現及功能性研究 [2009/08/01 ~ 2010/07/31]
    4. 以轉錄體學方式分析石斑魚免疫細胞之免疫相關基因及其表現 [2009/08/01 ~ 2010/07/31]
    5. 建立點帶石斑魚重組TNF-α蛋白分子表現及其功能性分析 [2009/07/01 ~ 2010/02/28]
    6. 石斑魚腫瘤壞死因子基因選殖與其在魚苗發展階段基因表現及功能性研究 [2008/08/01 ~ 2009/07/31]

     

    專書專章著作:

    1. JHY Lin , CC Yu, CC Lin and HL Yang, 2005, An oral delivery system for recombinant subunit vaccine to fish, Mydtlyng (ed): Fish Vaccinology, Dev Biol. Basel Karger 121:175-180

     

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