張惠雯 助理教授

研究領域:病毒分子致病機制(病毒毒力因子、病毒細胞接受體辨識、病毒與宿主交互作用)、動物用疫苗研發(減毒、死毒及次單位)

免疫組織化學 / 經濟動物病原核酸檢驗服務

擔任課程: 獸醫病理學、屍體解剖學、組織病理診斷學、獸醫魚病學、經濟動物診療實習
聯絡電話:02-33669899
子信箱:huiwenchang@ntu.edu.tw
歷:

2006 台灣大學獸醫系博士

2006-2011 荷蘭烏特列茲大學博士後研究員

2012-2014 美國哈佛醫學院博士後研究員

Office hours: 請同學以Email方式與老師約定時間; 歡迎大三以上獸醫系同學及研究生對病毒致病機轉研究有興趣者加入實驗室。




蔡沛學

近期學術著作:

  • 期刊論文:

    1. Chia-Yu Chang, Ivan-Chen Cheng, Yen-Chen Chang, Pei-Shiue Tsai, Seiu-Yu Lai, Yu-Liang Huang, Chian-Ren Jeng, Victor Fei Pang, Hui-Wen Chang (2019, Feb). Identification of Neutralizing Monoclonal Antibodies Targeting Novel Conformational Epitopes of the Porcine Epidemic Diarrhoea Virus Spike Protein. Scientific Reports , (9): 2529. 本人為通訊作者.
    2. Tsung-Lin Tsai, Chen-Chang Su, Ching-Chi Hsieh, Chao-Nan Lin, Hui-Wen Chang, Chen-Yu Lo, Ching-Houng Lin, Hung-Yi Wu (2018, Nov). Gene Variations in Cis-Acting Elements between the Taiwan and Prototype Strains of Porcine Epidemic Diarrhea Virus Alter Viral Gene Expression. Genes, Genes 2018, 9(12), 591; https://doi.org/10.3390/genes9120591. (SCI, 68/171 (Q2) in ‘Genetics & Heredity’).
    3. Chi-Fei Kao, Hue-Ying Chiou, Yen-Chen Chang, Cheng-Shun Hsueh, Chian-Ren Jeng, Pei-Shiue Tsai, Ivan-Chen Cheng, Victor Fei Pang, and Hui-Wen Chang (2018, Oct). The Characterization of Immunoprotection Induced by a cDNA Clone Derived from the Attenuated Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 Strain. Viruses, 10(10), 543; doi: 10.3390/v10100543. (SCI). MOST 106-2311-B-002-028-MY3. 本人為通訊作者.
    4. Wen-Ta Li, Lei-Ya Wang, Hui-Wen Chang, Wei-Cheng Yang, Chieh Lo, Victor Fei Pang, Meng-Hsien Chen, and Chian-Ren Jeng (2018, Sep). Th2 cytokine bias induced by silver nanoparticles in peripheral blood mononuclear cells of common bottlenose dolphins (Tursiops truncatus). PeerJ, doi: 10.7717/peerj.5432.
    5. Yamashita-Kawanishi N, Sawanobori R, Matsumiya K, Uema A, Chambers JK, Uchida K, Shimakura H, Tsuzuki M, Chang CY, Chang HW, Haga T. (2018, Aug). Detection of felis catus papillomavirus type 3 and 4 DNA from squamous cell carcinoma cases of cats in Japan.. J Vet Med Sci, 80(8):1236-1240.
    6. Ju-Yi Peng, Chia-Yu Chang, Chi-Fei Kao, Yen-Chen Chang, Cheng-Shun Hsueh, Chian-Ren Jeng, Ivan-Chen Cheng, Victor Fei Pang, Pei-Shiue Tsai, Hui-Wen Chang (2018, Jul). Different Intestinal Tropism of the G2b Taiwan Porcine Epidemic Diarrhea Virus-Pintung 52 Strain in Conventional 7-Day-Old Piglets. The Veterinary Journal, 237, 69-75. (SCI, 23/138; veterinary science). MOST 105-2622-B-002-014-CC2. 本人為通訊作者.
    7. Chang, C.-Y., Hsu, W.-T., Chao, Y.-C., Chang, H.-W (2018, Jun). Display of Porcine Epidemic Diarrhea Virus Spike Protein on Baculovirus to Improve Immunogenicity and Protective Efficacy.. Viruses , 2018, 10 (7), 346.. (SCI, 11/35/Virology). MOST 106-3114-B-003-001. 本人為通訊作者.
    8. Heng-Wei Lee, Ming-Chung Deng, Chu-Hsiang Pan, Hui-Wen Chang, Ivan- Chen Cheng (2018, Jun). Neutralizing monoclonal antibodies against porcinophilic Foot-and-mouth disease virus mapped to antigenic site 2 by utilizing novel mutagenic virus-like particles to detect the antigenic change. Veterinary Microbiology, https://doi.org/10.1016/j.vetmic.2018.06.002.
    9. Shirato K, Chang HW, Rottier PJM. (2018, Jun). Differential susceptibility of macrophages to serotype II feline coronaviruses correlates with differences in the viral spike protein.. Virus Research, 255:14-23.. (SCI, 18/35/Virology).
    10. Tse-En Wang, Sheng-Hsiang Li, Shiori Minabe, Amanda L Anderson, Matthew D Dun, Kei-Ichiro Maeda, Fuko Matsuda, Hui-Wen Chang, Brett Nixon, Pei- Shiue Jason Tsai (2018, May). Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal luminal distribution with Segment-Specific sperm surface associations. Biology of Reproduction, https://doi.org/10.1093/biolre/ioy125. (SCI, 5/29 reproduction).
    11. Yen-Chen Chang, Chia-Yu Chang, Pei-Shiue Tsai, Hue-Ying Chiou, Chian-Ren Jeng, Victor Fei Pang, Hui-Wen Chang (2018, May). Efficacy of Heat-Labile Enterotoxin B Subunit-Adjuvanted Parenteral Porcine Epidemic Diarrhea Virus Trimeric Spike Subunit Vaccine in Piglets. Applied microbiology and biotechnology, https://doi.org/10.1007/s00253-018-9110-6. (SCI, (44/160)/biotechnology and microbiology ). 本人為通訊作者.
    12. Tse-En J. Wang, Hung-Ting Liu, Yu-Hua Lai, Tong-Rong Jan, Naohiro Nomura, Hui-Wen Chang, Chi-Chung Chou, Ya-Jane Lee and Pei-Shiue J. Tsai (2018, Apr). Honokiol, a Polyphenol Natural Compound, Attenuates Cisplatin-Induced Acute Cytotoxicity In Renal Epithelial Cells Through Cellular Oxidative Stress And Cytoskeleton Modulations. Frontiers in Pharmacology, doi: 10.3389/fphar.2018.00357. (SCI, 33/257 Pharmacology).
    13. Wen-Ta Li, Hui-Wen Chang, Meng-Hsien Chen, Hue-Ying Chiou, Bang-Yeh Liou, Victor Fei Pang, Wei-Cheng Yang, Chian-Ren Jeng (2018, Apr). Investigation of silver (Ag) deposition in tissues from stranded cetaceans by autometallography (AMG). Environmental Pollution, 235:534-545. (SCI, 25/231 pollution).
    14. Wen-Ta Li, Hui-Wen Chang, Wei-Cheng Yang, Chieh Lo, Lei-Ya Wang, Victor Fei Pang, Meng-Hsien Chen, Chian-Ren Jeng (2018, Apr). Immunotoxicity of Silver Nanoparticles (AgNPs) on the Leukocytes of Common Bottlenose Dolphins (Tursiops truncatus). Scientific report. (SCI, 13/83 multidisciplinary science).
    15. Cheng-Shun Hsueh, Wen-Ta Li, Chian-Ren Jeng, Victor Fei Pang, Hui-Wen Chang (2018, Feb). Diffuse-Type Gastric Mucinous and Signet Ring Cell Adenocarcinoma in a Captive California King Snake (Lampropeltis getula california). Journal of Comparative Pathology. (Accepted). (SCI, (44/136)/veterinary sciences). 本人為通訊作者.
    16. Jane-Fang Yu, Yu-Hua Lai, Tse-En Wang, Yu-Syuan Wei, Yu-Jia Chang, Sheng- Hsiang Li, Shih-Chien Chin, Radhika Joshi, Hui-Wen Chang, and Pei-Shiue Tsai (2018, Feb). The effects of type I collagenase on the degelification of chimpanzee (Pan troglodytes) semen plug and sperm quality.. BMC Veterinary Research , 14(1):58 . (SCI, 18/138, veterinary science).
    17. T-C Cham, Y-C Chang, P-S Tsai, C-H Wu, H-W Chen, C-R Jeng, Victor F Pang, H-W Chang (2017, Aug). Determination of the cell tropism of serotype 1 feline infectious peritonitis virus using the spike affinity histochemistry in paraffin- embedded tissues. Microbiology and immunology, Aug;61(8):318-327. doi: 10.1111/1348-0421.12498.. (SCI, (89/123)/Microbiology). 本人為通訊作者.
    18. H-T Liu, Y-W Kuo, H-W Chang, Y-J Lee, P-S J Tsai (2017, Jul). Arginine Vasopressin Promotes Redistribution of Adhesion Junction Protein E-Cadherin in Kidney Epithelial Cells.. Taiwan Veterinary Journal, 43(3);1-10.
    19. Y-W Kuo , R Joshi , T-E Wang, H-W Chang, S-H Li, J-N Hsiao, P-S. J Tsai (2017, Jun). Identification, Characterization and Purification of Porcine Quiescin Q6 Sulfhydryl Oxidase 2 Protein. . BMC Veterinary Research, 2017. (SCI, 18/138, veterinary science).
    20. Y-C Chang, C-F Kao, C-Y Chang, C-R Jeng, P-S J Tsai, F Victor Pang, H-Y Chiou, J-Y Peng, I-C Cheng, H-W Chang (2017, May). Evaluation and comparison of the pathogenicity and host immune responses induced by a G2b Taiwan porcine epidemic diarrhea virus (strain Pintung 52) and its highly cell- culture passaged strain in conventional 5-week-old pigs. viruses, 19;9(5). pii: E121. doi: 10.3390/v9050121.. (SCI, 11/35/Virology). MOST 103-2321-B-002- 077-MY3. 本人為通訊作者.
    21. C-Y Chang, S H Kuo, Y-W Peng, C-H Lin, Y-K Lee, Y-C Chen, H-W Chang (2017, Jan). Diagnosis and treatments of feline infectious peritonitis: an update . Taiwan Veterinary Journal, 43 (1): 1-9. 本人為通訊作者.
    22. H-Y Chiou, T-L Huang, M-C Deng, C-Y Chang, C-R Jeng, P-S J. Tsai, C Yang, F V Pang, H-W Chang (2017, Jan). Phylogenetic Analysis of the Spike (S) Gene of the New Variants of Porcine Epidemic Diarrhea Virus (PEDV) in Taiwan .Transboundary and Emerging Diseases , 64:157-166. . (SCI, 5/138(Veterinary Sciences)). MOST 103-2811-B-002-055. 本人為通訊作者.
    23. Li WT, Lo C, Su CY, Kuo H, Lin SJH, Chang HW, Pang VF, Jeng CR. (2017). Locally extensive meningoencephalitis caused by Miamiensis avidus (syn. Philasterides dicentrarchi) in a zebra shark. Dis Aquat Org , 126:167-172. . (SCI, 26/138, veterinary science)
    24. H-T Liu, L-T Chen, T-F Chuang, H-W Chang, H-H Kao, P-S Jason Tsai (2016, Dec). The effects of vasopressin on the progression of chronic kidney disease and its potential treatment using vasopressin receptor antagonists in the field of veterinary medicine . Taiwan Veterinary Journal, http://dx.doi.org/10.1142/S1682648515300051.
    25. W-T Li, H-W Chang, C-R Jeng, C-H Liu, F-I Wang, L-J Chang, V F Pang (2016, Nov). Concurrent spindle-cell thymoma and thymic cysts in a Barbary sheep (Ammotragus lervia): case report and review of the literature.. J Vet Diagn Invest. , 28(6):744-749. . (SCI, 51/138 veterinary science).
    26. W-T Li, H-W Chang, V F Pang, F-I Wang, C-H Liu, T-Y Chen, J-C Guo, T Wada, C-R Jeng (2016, Nov). Mycolactone-producing Mycobacterium marinum infection in captive Hong Kong warty newts (Paramesotriton hongkongensis) and pathological evidence of impaired host immune function. Diseases of Aquatic Organisms, 123(3):239-249.. (SCI, 26/138, veterinary science).
    27. C Yang, Y-C Chang, C-Y Chang, P-S Tsai, C-R Jeng, V F Pang, I-C Cheng, H-W Chang (2016, Sep). Identification of a highly transfectable cell line permissive to porcine epidemic diarrhea virus infection and replication . Taiwan Veterinary Journal, DOI: http://dx.doi.org/10.1142/S1682648515500286. MOST 103-2321- B-002-077-MY3. 本人為通訊作者.
    28. Y-C Chang, C-R Jeng, V F Pang, Y-H Lai, C-Y Lien, P-J Wang, C-C Guo, H-W Chang (2016, Sep). Post-anesthesia hiatus hernia in a bengal tiger (Panthera tigris tigris) . Taiwan Veterinary Journal , Vol. 42, No. 03 : pp. 171-175. 本人為 通訊作者.
    29. Chiou HY, Huang YL, Deng MC, Chang CY, Jeng CR, Tsai PS, Yang C, Pang VF, Chang HW (2015, Apr). Phylogenetic Analysis of the Spike (S) Gene of the New Variants of Porcine Epidemic Diarrhea Virus (PEDV) in Taiwan. Transboundary and Emerging Diseases 2015 Apr 22. doi: 10.1111/tbed.12357. . (IF: 2.944; ranking 1/133 veterinary science)
    30. Chiou HY, Yeh KS, Jeng CR, Chang HW, Chang LJ, Wu YH, Chan FT and Pang VF(2015). Disease surveillance in rescued and road-killed wild-ranging carnivores in Taiwan. Taiwan Veterinary Journal, Vol. 41, No. 2 (2015) 73–84.
    31. Chang HW, Tartaglia LJ, Whitney JB, Lim SY, Sanisetty S, Lavine CL, Seaman MS, Rademeyer C, Williamson C, Ellingson-Strouss K, Stamatatos L, Kublin J, Barouch DH. (2014, Dec). Generation and Evaluation of Clade C Simian-Human Immunodeficiency Virus Challenge Stocks. Journal of Virology. (SCI, 7/33, Virology).
    32. Tsai YC, Jeng CR, Chang CC, Hsiao SH, Chang HW, Lin CM, Chia MY, Wan CH, Pang VF. 2014. Differences in the expression of innate immune response-modulating genes in blood monocytes between subclinically porcine circovirus type 2 (PCV2)-infected and PCV2-free pigs prior to and after lipopolysaccharide stimulation in vitro. Taiwan Vet J 40 (01): 37-48.
    33. Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. 2013. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature.2013 Oct 30. doi: 10.1038/nature12744. (IF: 42.351)
    34. Tsai YC*, Chang HW*, Jeng CR, Lin TL, Lin CM, Wan CH, Pang VF. The effect of infection order of porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus on dually infected swine alveolar macrophages.BMC Vet Res. 2012 Sep 25;8:174. doi: 10.1186/1746-6148-8-174. (*Equal contributors) (IF:1.861; ranking 18/143 veterinary science)
    35. Chang HW, Egberink HF, Halpin R, Spiro DJ, Rottier PJ. 2012. Spike protein fusion peptide and feline coronavirus virulence. Emerging Infectious Diseases Vol. 18, No. 7, July 2012. (IF:5.993; ranking 4/70 infectious disease)
    36. Chang HW, Egberink HF, Rottier PJ. 2011. Sequence analysis of feline coronaviruses and the circulating virulent/avirulent theory. Emerging Infectious Diseases Vol. 17, No. 4. (IF:6.169; ranking 5/70 infectious disease)
    37. Chia MY, Hsiao SH, Chan HT, Do YY, Huang PL, Chang HW, Tsai YC, Lin CM, Pang VF, Jeng CR. 2011. Evaluation of the immunogenicity of a transgenic tobacco plant expressing the recombinant fusion protein of GP5 of porcine reproductive and respiratory syndrome virus and B subunit of Escherichia coli heat-labile enterotoxin in pigs. Vet Immunol Immunopathol. 140:215-25. (IF:2.076; ranking 10/145 veterinary science)
    38. Chang HW, de Groot RJ, Egberink HF, Rottier PJ. 2010. Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene. J Gen Virol. 91:415-20. (IF: 3.568; ranking 11/33 virology)
    39. Chia MY, Hsiao SH, Chan HT, Do YY, Huang PL, Chang HW, Tsai YC, Lin CM, Pang VF, Jeng CR. 2010. The immunogenicity of DNA constructs co-expressing GP5 and M proteins of porcine reproductive and respiratory syndrome virus conjugated by GPGP linker in pigs. Vet Microbiol 146: 189-99. (IF: 3.256; ranking 3/145 veterinary science)
    40. Tsai YC, Jeng CR, Hsiao SH,Chang HW, Liu JJ, Chang CC, Lin CM, Chia MY, Pang VF. 2010.  Porcine circovirus type 2 (PCV2) induces cell proliferation, fusion, and chemokine expression in swine monocytic cells in vitro. Vet Res. 41:60 (IF:3.765; ranking 1/145 veterinary science)
    41. Chia MY, Hsiao SH, Chan HT, Do YY, Huang PL, Chang HW, Tsai YC, Lin CM, Pang VF, Jeng CR. 2010. Immunogenicity of recombinant GP5 protein of porcine reproductive and respiratory syndrome virus expressed in tobacco plant. Vet Immunol Immunopathol. 135(3-4):234-42. (IF: 2.176; ranking 13/145 veterinary science)
    42. Su BL, Chang HW, Lin CN, Pang VF, Chueh LL, Jeng CR. An update of aspects of feline immunodeficiency virus in Taiwan. Taiwan Vet J 35:167-173, 2009.
    43. Lin CM, Jeng CR,Chang HW, Guo IC, Huang YL, Tsai YC, Chia MY, Pang VF. 2008. Characterization of porcine circovirus type 2 (PCV2) infection in swine lymphocytes using mitogen-stimulated peripheral blood lymphocytes from healthy PCV2-carrier pigs. Vet Immunol Immunopathol. 124:355-66.  (IF: 1.907; ranking 12/135 veterinary science)
    44. Chang HW, Jeng CR, Lin CM, Liu JJ, Chang CC, Tsai YC, Chia MY, Pang VF. 2007. The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro. Vet Microbiol. 122:72-82. (IF: 2.01; ranking 7/133 veterinary science)
    45. Chang HW, Pang VF, Chen LJ, Chia MY, Tsai YC, Jeng CR. 2006. Bacterial lipopolysaccharide induces porcine circovirus type 2 replication in swine alveolar macrophages. Vet Microbiol. 115:311-9. (IF: 2.073; ranking 4/129 veterinary science)
    46. Chang HW, Jeng CR, Lin TL, Liu JJ, Chiou MT, Tsai YC, Chia MY, Jan TR, Pang VF. 2006. Immunopathological effects of porcine circovirus type 2 (PCV2) on swine alveolar macrophages by in vitro inoculation. Vet Immunol Immunopathol. 110:207-19. (IF: 1.994; ranking 8/129 veterinary science)
    47. Chang HW, Ho SY, Lo HF., Tu YC, Jeng CR, Liu CH, Wang FI, Pang VF. 2006. A vaccine-associated rhabdomyosarcoma with spinal epidural and pulmonary metastases in a cat. Vet Path 43: 55-8. (IF: 1.188; ranking 32/129 veterinary science)
    48. Chang HW, Jeng CR, Liu JJ, Lin TL, Chang CC, Chia MY, Tsai YC, Pang VF. 2005 . Reduction of porcine reproductive and respiratory syndrome virus (PRRSV) infection in swine alveolar macrophages by porcine circovirus 2 (PCV2)-induced interferon-alpha. Vet Microbiol 108:167-77.  (IF: 2.175; ranking 3/129 veterinary science)
    49. Lee YY, Chueh LL, Pang VF,Chang HW, Jeng CR. Detection of type 2 porcine circovirus by in situ hybridization. Taiwan Vet J 29(3):174-180.

     

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