蔡沛學 助理教授

繁殖生理與细胞生物學 (Reproductive Physiology and Cell Biology) 研究室 (獸一館101-102R)

實驗室網頁:http://jasonpstsai.wix.com/jt-lab-ntuvm

研究領域: 繁殖生理 (Reproductive Physiology)、细胞生物學 (Cell Biology) 、细胞膜蛋白與囊泡傳輸機制 (Membrane Protein and Intracellular Vesicle Trafficking)

擔任課程: 獸醫生殖學 (繁殖障礙與產科) 、基礎組專題討論、臨床討論、分子細胞生物學、 反芻動物疾病學

聯絡電話:Office:(02)3366-1290; Lab: (02)3366-1290

電子信箱:psjasontsai@ntu.edu.tw

學歷: 荷蘭烏特列支大學 (Utrecht University)生化與細胞生物學系博士

Office hours: 請同學以Email方式與老師約定時間




蔡沛學

近期學術著作:

  • 期刊論文

  1. Kuo YW, Li SH, Maeda KI, Gadella BM, Tsai PS*. Roles of Reproductive Tract on Modifications of Sperm Membrane Surface. Journal of Reproduction and Development 2016 Aug. 14. doi: 10.1002/mrd.22622. (SCI, IF:1.59, ranking 13/57 Agriculture, Dairy, Animal Science). http://www.ncbi.nlm.nih.gov/pubmed/27009019

  2. Kuo YW, Liu HT, Li SH, Maeda KI, Gadella BM, Tsai PS*. The involvement of epididymal secretory proteins in the selection process of sperm cells. Molecular Reproduction and Development 2016 Feb 8. doi: 10.1002/mrd.22622. (SCI, IF: 2.61, ranking 12/30 Reproductive Biology). http://www.ncbi.nlm.nih.gov/pubmed/26854495

  3. Chiou HY, Hung YL, Deng MC, Chang CY, Jeng CR, Tsai PS, Yang C, Pang VF, Chang HW*. Phylogenetic Analysis of the Spike (S) Gene of the New Variants of Porcine Epidemic Diarrhoea Virus in Taiwan. Transboundary and Emerging Diseases 2015, April 22, doi: 10.1111/tbed.12357. (SCI, IF: 2.94, ranking 1/133 Veterinary Science). http://www.ncbi.nlm.nih.gov/pubmed/25903998

  4. Florman H*, Cao WL, Jungnickel MK, Sutton KA, Tsai PS*. Coup d’oeil of Sperm. Molecular Reproduction and Development 2012, May;79(5):Fm i. doi: 10.1002/mrd.22039. (SCI, IF: 2.81, ranking 7/30 Reproductive Biology). http://www.ncbi.nlm.nih.gov/pubmed/22508555

  5. Tsai PS, Brewis IA, J. Van Maaren, Gadella BM*. Involvement Of Complexin 2 in Docking, Locking and Unlocking of diffeent SNARE complexes in induced Acrosome ExocytosisPLoS One. 2012;7(3):e32603. doi: 10.1371/journal.pone.0032603. Epub 2012 Mar 6 (SCI, IF: 4.41, ranking 12/86 Multidisciplinary Science). http://www.ncbi.nlm.nih.gov/pubmed/22412896

  6. Tsai PS, Van Haeften T, Gadella BM*. Preparation of the cortical reaction: maturation dependent migration of SNARE proteins, clathrin and complexin to the porcine oocyte’s surface blocks membrane traffic until fertilization. Biology of Reproduction 2011, 84:327-335. (SCI, IF: 4.14, ranking 2/30 Reproductive Biology). http://www.ncbi.nlm.nih.gov/pubmed/20944080

  7. Tsai PS, Garcia-Gil N, Colenbrander B, Van Haeften T, Gadella BM*. How pig sperm prepares to fertilize: acrosome docking and priming to the plasma membrane. PLoS ONE 2010 Jun 18;5(6):e11204. (SCI, IF: 4.41, ranking 12/86 Multidisciplinary Science). http://www.ncbi.nlm.nih.gov/pubmed/20585455

  8. Tsai PS, Gadella BM*. Molecular kinetics of proteins at the surface of porcine sperm before and during fertilization. Soc. Reprod. Fertil. Suppl. 2009;66:23-36. (SCI, IF=2.58, ranking 9/26 Reproductive Biology). http://www.ncbi.nlm.nih.gov/pubmed/19848264

  9. Gadella BM, Tsai PS, Boerke A, Brewis IA*. Sperm head membrane reorganisation during capacitation. International Journal of Developmental Biology 2008;52(5-6):473-80. (SCI, IF=2.61, ranking 35/41 Developmental Biology). http://www.ncbi.nlm.nih.gov/pubmed/18649260

  10. Boerke A, Tsai PS, Garcia-Gil N, Brewis IA, Gadella BM*. Capacitation-dependent reorganization of microdomains in the apical sperm head plasma membrane Functional relationship with zona binding and the zona-induced acrosome reaction. Theriogenology 2008 Nov;70(8):1188-96. (SCI, IF=2.08, ranking 9/135 Veterinary Science). http://www.ncbi.nlm.nih.gov/pubmed/18640708

  11. Tsai PS, De Vries KJ, De Boer-Brouwer M, Garcia-Gil N, Van Gestel RA, Colenbrander B, Gadella BM, Van Haeften T*. Syntaxin and VAMP association with lipid rafts depends on cholesterol depletion in capacitating sperm cells. Molecular Membrane Biology 2007 Jul-Aug;24(4):313-24. (SCI, IF=3.87, ranking 74/263, Biochemistry & Molecular Biology). http://www.ncbi.nlm.nih.gov/pubmed/17520487

  12. Wu JT, Tsai PS, Lee SL, Cheng FP*. Characterisation of the progesterone receptor on canine spermatozoa. Reprod. Fertil. Dev. 2005 17(7):733-741. (SCI, IF=2.62, ranking 15/30 Reproductive Biology). http://www.ncbi.nlm.nih.gov/pubmed/16364228

  13. Tsai PS, Nielen M., van der Horst GTJ, Colenbrander B., Heesterbeek JAP, Fentener van Vlissingen JM*. The effect of DNA repair defects on reproductive performance in nucleotide excision repair (NER) mouse models: An epidemiological approach. Transgenic Research 2005 14:845-857. (SCI, IF=2.3, ranking 74/163 Biotechnology and Applied Microbiology). http://www.ncbi.nlm.nih.gov/pubmed/16315091

  14. Cheng FP, Wu JT, Tsai PS, Chang CL, Lee SL, Lee WM, Fazeli A*. Effects of cryo-injury on progesterone receptor(s) of canine spermatozoa and its response to progesterone. Theriogenology 2005 64(4):844-854. (SCI, IF=2.08, ranking 9/135 Veterinary Science). http://www.ncbi.nlm.nih.gov/pubmed/16054490

  • 書籍著作 (Book Chapter):

  1. Tsai PS, Gadella BM. Molecular kinetics of proteins at the surface of porcine sperm before and during fertilization. Chapter 2, Control of Pig Reproduction VIII, 2009. Nottingham University Press. ISBN: 978-1-904761-39-6

  • 研討會論文 (Proceedings/Oral Presentation)

  1. H.T. Liu, Y.W. Kuo, Tsai PS*, Joint Conference between NTU and UTokyo. December 9th-10th 2015. Tokyo, Japan. The Relation Between Vasopressin on Chronic Kidney Disease.

  2. Y.W. Kuo, H.T. Liu, C.K.E.Mak, F.J. Shou, Tsai PS*, Joint Symposium of the 6th Veterinary Research and the 3rd Veterinary Education among Universities of Veterinary Medicine in East Asia. February 2nd-3rd 2015. Taipei, Taiwan. The Negative Impacts of Vasopressin on Kidney Epithelial Cells.

  3. Tsai PS, Gadella BM. Annual meeting of the Institute of Biomembranes. 28th-29th October 2010. Utrecht, the Netherlands. Stable docking of the acrosome to the sperm plasma membrane is a preparative step required for the mammalian fertilization (Invited presentation).

  4. Tsai PS, Gadella BM, Helms B. NWO-CW Annual meeting for Proteins, Lipids, Nucleus and Biomembranes. 7th-9th December 2009. Veldhoven, the Netherlands.

  5. Bart Gadella, Tsai PS. VIII Annual meeting for the Society of Reproduction and Fertility (SRF, ICPR). 31st May-4th June 2009. Banff, Canada. Molecular kinetics of proteins at the surface of porcine sperm before and during fertilization (Invited presentation).

  6. Tsai PS. Annual meeting for Dutch Veterinarian Science Day. November 22nd 2007. Zeist, the Netherlands. Capacitation-dependent formation of a SNARE protein complex involved in the acrosome reaction.

  7. Tsai PS. 40th Annual meeting for Society for the Study of Reproduction (SSR). July 21st-25th 2007. San Antonio, Texas, USA. SNARE redistribution during capacitation depends on association with lipid rafts.

  8. Tsai PS. NWO-CW Annual meeting for Lipids and Biomembranes. March 5th- 6th 2007. Lunteren, the Netherlands. Syntaxin and VAMP association with lipid rafts depends on cholesterol depletion in capacitating sperm cells. Awarded for “Best presentation 2007”.

  • 研討會論文 (Poster Presentation)

  1. H.T. Liu, Y.W. Kuo, C.K.E.Mak, F.J. Shou, Tsai PS, 7th World Congress on Preventive and Regenerative Medicine. November 7th-11th 2014. Taipei, Taiwan. The Effects of Vasopressin on Kidney Epithelial Cells Spreading and Wound Healing Abilities: The Cellular Aspects of Kidney Tubular Regeneration After Injury.

  2. Tsai PS, IA Brewis, B.M. Gadella Gordon Research Conference (Fertilization, Activation and Development). July 17th-22nd 2011. Holdness, NH, USA. How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.

  3. P.S. Tsai, N. Garcia-Gil, T. van Haeften, B.M. Gadella NWO-CW Annual meeting for Lipids and Biomembranes. December 6th-7th 2010. Veldhoven, the Netherlands. How pig sperm prepares to fertilize: stable acrosome docking to the plasma membrane.

  4. P.S. Tsai, T. van Haeften, B.M. Gadella NWO-CW Annual meeting for Lipids and Biomembranes. December 6th-7th 2010. Veldhoven, the Netherlands. Preparation of the cortical reaction: maturation dependent migration of SNARE proteins, clathrin and complexin to the porcine oocyte’s surface blocks membrane traffic until fertilization.

  5. P.S. Tsai, A. Boerke, N. Garcia, B. Colenbrander, J.B. Helms, T.A. van Haeften, B.M. Gadella NWO-CW Annual meeting for Lipids and Biomembranes. March 10th-11th 2008. Lunteren, the Netherlands. Capacitation of mammalian sperm leads to SNARE complex formation and docking of the plasma membrane with the acrosome.

  6. Boerke A., P.S. Tsai, G. van der Velde, B. Colenbrander, J.B. Helms, B.M. Gadella. NWO-CW Annual meeting for Lipids and Biomembranes. March 10th-11th 2008. Lunteren, the Netherlands. Capacitation-dependent clustering of sperm membrane microdomains with lipid raft-like features.

  7. Tsai PS. 40th Annual meeting for Society for the Study of Reproduction (SSR). July. 21st-25th 2007. San Antonio, Texas, USA. SNARE redistribution during capacitation depends on association with lipid rafts. Biology of Reproduction 2007 77:194–194.

  8. P.S. Tsai, M. Nielen, G.T.J. van der Horst, B. Colenbrander, J.A.P. Heesterbek& J.M. Fentener van Vlissingen. 10th FELASA symposium. June 11th-14th 2007, Villa Erba,. Cernobbio (Como), Italy. Mining the Animal data base (AMS) for the evaluation of reproductive performance in mutant mice: an epidemiological approach.

  9. N. Garcia-Gil, P.S. Tsai, A. Boerke, S. Bonet, B.M. Gadella. 8th International Meeting AERA. October 19th- 21st 2006. Murcia, Spain. Effect of Cryopreservation on the Association of Syntaxin 2 to the Lipid Raft. Reprod. in Domest. Anim. 2006 41(2):113

  10. P.S. Tsai, M. de Boer-Brouwer, N. Garcia-Gil, K.J. de Vries, B. Colenbrander, T.A.E. van Haeften, B.M. Gadella. Annual meeting for Dutch Veterinarian Science Day. May 12nd 2006. Zeist, the Netherlands. Syntaxin 2 association to the lipid rafts during cholesterol depletion in sperm cells. Awarded for “Jury Price 2006”.

  11. Tsai PS, Nielen M., van der Horst GTJ, Colenbrander B., Heesterbeek JAP, Fentener van Vlissingen JM. SVEPM Annual Conference. March 29th-April 1st, 2005. Nairn, Scotland. Reproductive performance in a colony of genetically modified mice.

Copyright © 2008 臺灣大學獸醫專業學院 School of Veterinary Medicine National Taiwan University | 版權聲明 | 建議使用瀏覽器 Firefox 3.x | 解析度 1024 x 768 以上 | 網站地圖