陳慧文 助理教授


傳染病免疫實驗室 (獸醫一館101室)
實驗室網頁:https://sites.google.com/site/winnichenlab/

研究領域:抗病毒藥物與疫苗之研發、病毒之致病與免疫機制、傳染病流行病學、微生物診斷方法開發

擔任課程獸醫病毒學及實習、獸醫免疫學、禽病學 、獸醫分子病毒學、病毒之感染與免疫專題討論

聯絡電話:(02) 3366-9450

<>E-mail:winnichen@ntu.edu.tw

學歷:國立臺灣大學獸醫學博士 (2010)

經歷:University of California San Diego 博士後研究 (-2012)
             La Jolla Institute for Allergy and Immunology 博士後研究 (-2013)

Office hours:請同學以Email方式與老師預約時間


張雅珮老師

近期學術著作:

  • 一、期刊論文:

    1. Lin SY, Li YT, Chen YT, Chen TC, Hu CMJ, Chen HW*. Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile. Scientific Reports. In Press. (2016) (*corresponding)
    2. Elong Ngono A, Chen HW, Tang WW, Joo Y, King K, Weiskopf D, Sidney J, Sette A, Shresta S. Protective role of cross-reactive CD8 T cells against dengue virus infection. EBioMedicine doi:10.1016/j.ebiom.2016.10.006 (2016).
    3. Chen HW*, Huang CY, Lin SY, Fang ZS, Hsu CH, Lin JC, Chen YI, Yao BY, Hu CMJ*. Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials. doi:10.1016/j.biomaterials.2016.08.018 (2016). (*corresponding)
    4. Chen HW*, Liu PF, Liu YT, Kuo S, Zhang XQ, Schooley RT, Rohde H, Gallo RL, Huang CM*. Nasal commensal Staphylococcus epidermidis counteracts influenza virus. Scientific Reports. doi: 10.1038/srep27870 (2016). (*corresponding)
    5. Chang KP, Kolli BK, Batchu R, Chen HW, Chow LC, Elliott R, Head J, Fan CK, Hung CH, Ji DD, Lun ZR, Manna L, Matsumoto Y, Ng DP,de Oliveira C, Melo S, Ozbel Y, Özbilgin A, Reynolds J, Sanjoba C, Shiao SH, Shih NY, Tsai CW, Vicente MG, Barré C, Volf P, Wu YL, Yu CL, Zhou XN. New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasites & Vectors. doi: 10.1186/s13071-016-1674-3 (2016).
    6. Wang LC, Huang D, Chen HW. Simultaneous subtyping and pathotyping of avian influenza viruses in chickens in Taiwan using reverse transcription loop-mediated isothermal amplification and microarray. Journal of Veterinary Medical Science 78:1223-1228, 2016.
    7. Chen HW, Hsiao TH, Wang CH. Detection of anti-reticuloendotheliosis antibody by enzyme-linked immunosorbent assay using envelope protein expressed in baculovirus. Taiwan Veterinary Journal 42:165-170, 2016.
    8. Chen HW, King K, Tu J, Sanchez M, Luster AD, Shresta S. The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus. Journal of Immunology 191:4194-4201, 2013.
    9. Chen HW, Cheng JX, Liu MT, King K, Peng JY, Zhang XQ, Wang CH, Shresta S, Schooley RT, Liu YT. Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses. Antiviral Research 99:371-382, 2013.
    10. Cohen M, Zhang XQ, Senaati HP, Chen HW, Varki NM, Schooley RT, Gagneux P. Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase. Virology Journal 10:321-333, 2013.
    11. Wu NH, Tsai WT, Chen HW, Wang LC, Wang CH. Detection of anti-reticuloendotheliosis virus antibody by blocking enzyme-linked immunosorbent assay with expression envelope protein. Avian Diseases 57:71-75, 2013.
    12. Huang YP, Chen HW, Wang CH. Review: Worldwide epidemiology of infectious bronchitis virus variants. Taiwan Veterinary Journal 38:258-269, 2012.
    13. Hong HW, Cheng IC, Chen HW, Wang CH. Comparison of NP and M primers for avian influenza virus detection by reverse transcription polymerase chain reaction. Taiwan Veterinary Journal 38:213-220, 2012.
    14. Chen HW, Wang CH, Cheng IC. A type-specific blocking ELISA for the detection of infectious bronchitis virus antibody. Journal of Virological Methods173:7-12, 2011.
    15. Hsu MF, Chen HW, Chen CF, Wang CH. The serologic prevalence of subgroup J avian leukosis virus in some chickens in Taiwan in 2010. Taiwan Veterinary Journal 37:227-223, 2011.
    16. Tsai WT, Chen ZF, Chen HW, Chang SW, Lee GG, Wang CH. Reticuloendotheliosis virus infection in Taiwan Country Chickens. Taiwan Veterinary Journal 37:278-283, 2011.
    17. Chen HW, Wang CH. A multiplex RT-PCR assay for the genotyping of avian infectious bronchitis viruses. Avian Diseases54:104-108, 2010.
    18. Chen HW, Huang YP, Wang CH. Identification of intertypic recombinant infectious bronchitis viruses from slaughtered chickens. Poultry Science 89:439-446, 2010.
    19. Chen HW, Huang YP, Wang CH. Identification of Taiwan and China-like recombinant avian infectious bronchitis viruses in Taiwan. Virus Research 140:121-129, 2009.

    二、國際研討會:

    1. Chen HW, Li YT, Chen TC, Tsai HF, Wang CH. Emerging IBV variants: the genotypes, serotypes and pathotypes. 2016. American Association of Avian Pathologists Meeting. San Antonio, TX.
    2. Hu CMJ, Chen HW. Cell membrane cloaked nanoparticles for biologically inspired drug delivery. 2015. The 13th US-Japan Symposium on Drug Delivery Systems. Maui, HI.
    3. Chien CY, Liu MT, Chang SY, Chang SC, Juang RH, Chen HW. Preparation and immunogenicity evaluation of influenza A/H7N9 virus-like particles. 2015. Oxford Influenza 2015. Oxford, UK.
    4. Peng JY, Wang CH, Chen HW. Molecular and serological epidemiology of avian influenza virus subtype H6N1 in Taiwan. 2015. American Association of Avian Pathologists Meeting. Boston, MA.
    5. Jian CZ, Cheng IC, Wang CH, Chen HW. Preparation and characterization of monoclonal antibodies against the nucleocapsid protein of avian infectious bronchitis virus. 2015. American Society for Virology 34th Annual Meeting. London, Canada.
    6. Chen HW, Peng JY, Lee HC, He JL, Huang YP, Wang CH. Evolutionary changes in the receptor-binding site of the hemagglutinin protein in the avian influenza H6N1 virus may contribute to interspecies transmission. 2014. American Association of Avian Pathologists Meeting. Denver, CO.
    7. Chen HW, King K, Tu J, Sanchez M, Luster AD, Shresta S. The roles of IRF3 and IRF7 in innate antiviral immunity against dengue virus. 2013. American Society for Virology 32nd Annual Meeting. State College, PA.
    8. Chen HW, Wang CH. Characterization of hemagglutination activity of infectious bronchitis viruses and cell-associated hemadsorption activity of baculovirus expressed S1 glycoprotein. 2012. American Association of Avian Pathologists Meeting. San Diego, CA.
    9. Chen HW, Wang CH. Development of a type-specific blocking ELISA for the detection of infectious bronchitis virus antibody. 2010. American Association of Avian Pathologists Meeting. Atlanta, GA.
    10. Chen HW, Wang CH. A multiplex RT-PCR assay for the genotyping of avian infectious bronchitis viruses. 2009. American Society for Virology 28th Annual Meeting. Vancouver, Canada.
    11. Chen HW, Huang YP, Wang CH. Avian infectious bronchitis viruses identified in poultry slaughter houses exhibit wide genetic and antigenic varieties. 2009. 6th International Symposium on Avian Corona- and Pneumovirus and Complicating Pathogens. Rauischholzhausen, Germany.
    12. Chen HW, Wang CH. Characterization and application of monoclonal antibodies to avian infectious bronchitis virus. 2007. 15th Congress of the World Veterinary Poultry. Beijing, China.

    三、執行中研究計畫:

    1. 可裝載佐劑之奈米載體用於流感病毒疫苗的研發 (科技部補助, 8/1/2016-7/31/2019)
    2. 合成仿生病毒奈米粒子作為MERS冠狀病毒疫苗之應用 (科技部補助, 1/1/2016-12/31/2018)
    3. 家禽冠狀病毒變異株之病原性研究與防治 (科技部補助, 8/1/2014-7/31/2017)
    4. 桿狀病毒生產H7N9流感病毒蛋白與類病毒顆粒以建置疫苗與診斷平台 (科技部補助,3/1/2014-2/28/2016)
    5. 開發檢測家禽傳染性支氣管炎病毒之免疫色層分析測試片及具血清型別特異性之阻斷型酵素連結免疫分析法 (農委會補助,1/1/2014-12/31/2015)
    6. 寵物傳染病分析儀之產品確效比對 (產學合作,5/1/2015-12/31/2016)
    7. 合成仿生病毒奈米粒子作為MERS冠狀病毒疫苗之應用 (衛福部人才培育計畫,指導學生:黃湞鈺,4/1/2016-9/30/2016)
    8. 以桿狀病毒表現系統表現之家禽傳染性支氣管炎病毒結構蛋白進行次單位疫苗之發展 (科技部大專生研究計畫,指導學生:簡采甄,7/1/2015-2/28/2016)
    9. 研究 v-ATPase 抑制物 diphyllin 對貓傳染性腹膜炎病毒之抗病毒活性及其作用機制 (科技部大專生研究計畫,指導學生:王文伶,7/1/2015-2/28/2016)
    10. H6N1流感類病毒顆粒之製備與作為疫苗之效果評估 (衛福部人才培育計畫,指導學生:施浩榆,4/1/2015-9/30/2015)
    11. 家禽傳染性支氣管炎病毒單株抗體之製備與分析 (科技部大專生研究計畫,指導學生:簡采甄,7/1/2014-2/28/2015)
    12. 台灣家禽流行性感冒H6N1亞型病毒之分子暨血清流行病學調查 (衛福部人才培育計畫,指導學生:彭茹憶,4/1/2014-9/30/2014)

    四、獲獎記錄:

    2016/09 生物界面科學與工程國際研討會最佳海報獎 (指導學生:黃湞鈺)
    2016/08 科技部獎勵新聘特殊優秀人才補助
    2016/06 臺灣大學生物資源暨農學院優良教師
    2015/08 科技部獎勵新聘特殊優秀人才補助
    2014/12 中華民國獸醫學會學術研討會論文優等獎 (指導學生:彭茹憶)
    2013/11 中華民國獸醫學會學術研討會論文優等獎 (指導學生:彭茹憶)
    2011/12 科技部海外博士後研究獎學金
    2010/06 台灣大學生物資源暨農學院學術論文獎
    2009/05 中華民國獸醫學會學術研討會論文優等獎