陳慧文 副教授


傳染病免疫實驗室 (獸醫一館101室)
實驗室網頁:https://sites.google.com/site/winnichenlab/

犬貓病原核酸診斷服務(點擊連結)

研究領域:抗病毒藥物與疫苗之研發、病毒之致病與免疫機制、傳染病流行病學、微生物診斷方法開發

擔任課程:獸醫病毒學及實習、獸醫免疫學、禽病學、病毒之感染與免疫專題討論

聯絡電話:(02) 3366-9450

E-mail:winnichen@ntu.edu.tw

學歷:國立臺灣大學獸醫學博士 (2010)

經歷:University of California San Diego 醫學院 博士後研究 (-2012)
             La Jolla Institute for Allergy and Immunology 疫苗開發部 博士後研究 (-2013)

Office hours:請同學以Email方式與老師預約時間


陳慧文老師

近期學術著作:

  • 一、期刊論文:

    1. Chen HW, Fang ZS, Chen YT, Chen YI, Yao BY, Cheng JY, Chien CY, Hu CMJ. Targeting and Enrichment of viral pathogen by cell membrane cloaked magnetic nanoparticles for enhanced detection. ACS Applied Materials & Interfaces doi:10.1021/acsami.7b09931, 2017.
    2. 1. Hu CMJ, Chang WS, Fang ZS, Chen YT, Wang WL, Tsai HH, Chueh LL, Takano T, Hohdatsu T, Chen HW.. Nanoparticulate vacuolar ATPase blocker exhibits potent host targeted antiviral activity against feline coronavirus. Scientific Reports doi:10.1038/s41598-017-13316-0, 2017.
    3. Lin SY, Chen HW. Infectious bronchitis virus variants: molecular analysis and pathogenicity investigation. International Journal of Molecular Sciences doi:10.3390/ijms18102030, 2017.
    4. Cham TC, Chang YC, Tsai PS, Wu CH, Chen HW., Jeng CR, Pang F, Chang HW. Determination of the cell tropism of serotype 1 feline infectious peritonitis virus using the spike affinity histochemistry in paraffin-embedded tissues. Microbiology and Immunology 61:318-327, 2017.
    5. Chattopadhyay S, Chen JY, Chen HW., Hu CMJ. Nanoparticles vaccines adopting virus-like features for enhanced immune potentiation. Nanotheranostics doi:10.7150/ntno.19796, 2017.
    6. Hu CMJ, Chien CY, Liu MT, Fang ZS, Chang SY, Juang RH, Chang SC, Chen HW. Multi-antigen avian influenza A (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models. BMC Biotechnology doi:10.1186/s12896-016-0321-6, 2017.
    7. Lin SY, Li YT, Chen YT, Chen TC, Hu CMJ, Chen HW. Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile. Scientific Reports doi:10.1038/srep37725, 2016.
    8. Elong Ngono A, Chen HW, Tang WW, Joo Y, King K, Weiskopf D, Sidney J, Sette A, Shresta S. Protective role of cross-reactive CD8 T cells against dengue virus infection. EBioMedicine doi:10.1016/j.ebiom.2016.10.006 (2016).
    9. Chen HW*, Huang CY, Lin SY, Fang ZS, Hsu CH, Lin JC, Chen YI, Yao BY, Hu CMJ*. Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials. doi:10.1016/j.biomaterials.2016.08.018 (2016). (*corresponding)
    10. Chen HW*, Liu PF, Liu YT, Kuo S, Zhang XQ, Schooley RT, Rohde H, Gallo RL, Huang CM*. Nasal commensal Staphylococcus epidermidis counteracts influenza virus. Scientific Reports. doi: 10.1038/srep27870 (2016). (*corresponding)
    11. Chang KP, Kolli BK, Batchu R, Chen HW, Chow LC, Elliott R, Head J, Fan CK, Hung CH, Ji DD, Lun ZR, Manna L, Matsumoto Y, Ng DP,de Oliveira C, Melo S, Ozbel Y, Özbilgin A, Reynolds J, Sanjoba C, Shiao SH, Shih NY, Tsai CW, Vicente MG, Barré C, Volf P, Wu YL, Yu CL, Zhou XN. New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasites & Vectors. doi: 10.1186/s13071-016-1674-3 (2016).
    12. Wang LC, Huang D, Chen HW. Simultaneous subtyping and pathotyping of avian influenza viruses in chickens in Taiwan using reverse transcription loop-mediated isothermal amplification and microarray. Journal of Veterinary Medical Science 78:1223-1228, 2016.
    13. Chen HW, Hsiao TH, Wang CH. Detection of anti-reticuloendotheliosis antibody by enzyme-linked immunosorbent assay using envelope protein expressed in baculovirus. Taiwan Veterinary Journal 42:165-170, 2016.
    14. Chen HW, King K, Tu J, Sanchez M, Luster AD, Shresta S. The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus. Journal of Immunology 191:4194-4201, 2013.
    15. Chen HW, Cheng JX, Liu MT, King K, Peng JY, Zhang XQ, Wang CH, Shresta S, Schooley RT, Liu YT. Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses. Antiviral Research 99:371-382, 2013.
    16. Cohen M, Zhang XQ, Senaati HP, Chen HW, Varki NM, Schooley RT, Gagneux P. Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase. Virology Journal 10:321-333, 2013.
    17. Wu NH, Tsai WT, Chen HW, Wang LC, Wang CH. Detection of anti-reticuloendotheliosis virus antibody by blocking enzyme-linked immunosorbent assay with expression envelope protein. Avian Diseases 57:71-75, 2013.
    18. Huang YP, Chen HW, Wang CH. Review: Worldwide epidemiology of infectious bronchitis virus variants. Taiwan Veterinary Journal 38:258-269, 2012.
    19. Hong HW, Cheng IC, Chen HW, Wang CH. Comparison of NP and M primers for avian influenza virus detection by reverse transcription polymerase chain reaction. Taiwan Veterinary Journal 38:213-220, 2012.
    20. Chen HW, Wang CH, Cheng IC. A type-specific blocking ELISA for the detection of infectious bronchitis virus antibody. Journal of Virological Methods173:7-12, 2011.
    21. Hsu MF, Chen HW, Chen CF, Wang CH. The serologic prevalence of subgroup J avian leukosis virus in some chickens in Taiwan in 2010. Taiwan Veterinary Journal 37:227-223, 2011.
    22. Tsai WT, Chen ZF, Chen HW, Chang SW, Lee GG, Wang CH. Reticuloendotheliosis virus infection in Taiwan Country Chickens. Taiwan Veterinary Journal 37:278-283, 2011.
    23. Chen HW, Wang CH. A multiplex RT-PCR assay for the genotyping of avian infectious bronchitis viruses. Avian Diseases54:104-108, 2010.
    24. Chen HW, Huang YP, Wang CH. Identification of intertypic recombinant infectious bronchitis viruses from slaughtered chickens. Poultry Science 89:439-446, 2010.
    25. Chen HW, Huang YP, Wang CH. Identification of Taiwan and China-like recombinant avian infectious bronchitis viruses in Taiwan. Virus Research 140:121-129, 2009.

    二、國際研討會:

    1. Lin SY, Yao BY, Hu CMJ, Chen HW. Nanoparticulate CpG enhances chicken immune response. Avian Immunology Research Group 2018. Oxford, UK.
    2. Wen YC, Zhu WZ, Chang CF, Wang CH, Chen HW. Genetics, receptor binding, and pathogenicity investigation of H6 avian influenza virus in Taiwan. 2018. American Association of Avian Pathologists Meeting. Denver, CO.
    3. Chen YT, Hu CMJ, Chen HW. Vacuolar ATPase inhibiting nanoparticles exhibit potent host-targeted antiviral activity against influenza viruses. 2018. Negative Strand Virus Meeting. Verona, Italy
    4. Wu SH, Yang SH, Yang TC, Chen HW. Avian bornavirus infection among psittacines in Taiwan. 2018. The 34th World Veterinary Association Congress. Barcelona, Spain.
    5. Lin SY, Chen YT, Chen HW. Diversity of nsp 3 and nsp 16 of infectious bronchitis virus isolated in Taiwan. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
    6. Fang ZS, Hsieh CJ, Chen YT, Cheng JY, Yao BY, Hu CMJ, Chen HW. Biomembrane coated nanoparticles for influenza virus targeting and isolation. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
    7. Zhu WZ, Wen YC, Chen TC, Lin SY, Chen HW. Avian influenza H6 virus-like particles: Immunogenicity evaluation in murine and avian models. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
    8. Wen YC, Zhu WZ, Chen HW. Genetics, receptor binding, replication and mammalian adaptation of H6 avian influenza viruses in Taiwan. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
    9. Chen YT, Fang ZS, Chang WS, Chuang HF, Hu CMJ, Chen HW. Antiviral efficacy of diphyllin nanoparticles against influenza viruses. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
    10. Huang CY, Lin CW, Tseng CT, Hu CMJ, Chen HW. A STING agonist-loaded viromimetic nanoparticle for MERS-CoV vaccination. 2018. The 9th Joint Symposium of Veterinary Research in East Asia. Seoul, Korea.
    11. Chen HW., Wen YC, Zhu WZ. Assessment of Genetic, Antigenic, and Pathological Features of H6 Avian Influenza Virus in Taiwan. 2018. Global Alliance for Research on Avian Diseases. Hanoi, Vietnam.
    12. Huang CY, Lin CW, Hu CMJ, Chen HW. Preparation and characterization of synthetic avian coronavirus-like particle using gold nanoparticles. 2017. Virus-like Particle & Nano-particle Vaccines. Singapore.
    13. Lin SY, Li YT, Chen YT, Chen TC, Hu CMJ, Chen HW. Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile. 2017. American Association of Avian Pathologists Meeting. Indianapolis, IN.
    14. Chang WS, Wang WL, Fang ZS, Chueh LL, Takano T, Hohdatsu T, Hu CMJ, Chen HW. Nanoparticulate v-ATPase blocker exhibits potent antiviral activity against feline peritonitis virus. 2017. International Union of Microbiological Societies Meeting. Singapore.
    15. Chen HW., Huang CY, Lin SY, Fang ZS, Hsu CH, Lin JC, Chen YI, Yao BY, Hu CMJ. Synthetic virus-like nanoparticles assembled via protein corona formation enable effective antiviral vaccination. 2017. European Material Research Society 2017 Spring Meeting. Strasbourg, France.
    16. Chen HW., Li YT, Chen TC, Tsai HF, Wang CH. Emerging IBV variants: the genotypes, serotypes and pathotypes. 2016. American Association of Avian Pathologists Meeting. San Antonio, TX.
    17. Hu CMJ, Chen HW. Cell membrane cloaked nanoparticles for biologically inspired drug delivery. 2015. The 13th US-Japan Symposium on Drug Delivery Systems. Maui, HI.
    18. Chien CY, Liu MT, Chang SY, Chang SC, Juang RH, Chen HW. Preparation and immunogenicity evaluation of influenza A/H7N9 virus-like particles. 2015. Oxford Influenza 2015. Oxford, UK.
    19. Peng JY, Wang CH, Chen HW. Molecular and serological epidemiology of avian influenza virus subtype H6N1 in Taiwan. 2015. American Association of Avian Pathologists Meeting. Boston, MA.
    20. Jian CZ, Cheng IC, Wang CH, Chen HW. Preparation and characterization of monoclonal antibodies against the nucleocapsid protein of avian infectious bronchitis virus. 2015. American Society for Virology 34th Annual Meeting. London, Canada.
    21. Chen HW, Peng JY, Lee HC, He JL, Huang YP, Wang CH. Evolutionary changes in the receptor-binding site of the hemagglutinin protein in the avian influenza H6N1 virus may contribute to interspecies transmission. 2014. American Association of Avian Pathologists Meeting. Denver, CO.
    22. Chen HW, King K, Tu J, Sanchez M, Luster AD, Shresta S. The roles of IRF3 and IRF7 in innate antiviral immunity against dengue virus. 2013. American Society for Virology 32nd Annual Meeting. State College, PA.
    23. Chen HW, Wang CH. Characterization of hemagglutination activity of infectious bronchitis viruses and cell-associated hemadsorption activity of baculovirus expressed S1 glycoprotein. 2012. American Association of Avian Pathologists Meeting. San Diego, CA.
    24. Chen HW, Wang CH. Development of a type-specific blocking ELISA for the detection of infectious bronchitis virus antibody. 2010. American Association of Avian Pathologists Meeting. Atlanta, GA.
    25. Chen HW, Wang CH. A multiplex RT-PCR assay for the genotyping of avian infectious bronchitis viruses. 2009. American Society for Virology 28th Annual Meeting. Vancouver, Canada.
    26. Chen HW, Huang YP, Wang CH. Avian infectious bronchitis viruses identified in poultry slaughter houses exhibit wide genetic and antigenic varieties. 2009. 6th International Symposium on Avian Corona- and Pneumovirus and Complicating Pathogens. Rauischholzhausen, Germany.
    27. Chen HW, Wang CH. Characterization and application of monoclonal antibodies to avian infectious bronchitis virus. 2007. 15th Congress of the World Veterinary Poultry. Beijing, China.

    三、獲獎記錄:

    2018 入選參展科技部「2018 創新技術博覽會」
    2018 國立臺灣大學教研人員彈性加給
    2018 國立臺灣大學優良教師
    2018 國家衛生研究院年輕學者研究發展獎助
    2018 中華民國獸醫學會學術研討會論文優等獎 (指導學生:温意琪)
    2017 中華民國獸醫學會學術研討會論文優等獎 (指導學生:陳宥廷)
    2017 中華民國獸醫學會學術研討會論文優等獎 (指導學生:方紫珣)
    2017 科技部獎勵新聘特殊優秀人才獎助
    2016 衛福部大專生及研究生優秀著作獎 (指導學生:黃湞鈺)
    2016 中華民國獸醫學會學術研討會論文優等獎 (指導學生:黃湞鈺)
    2016 生物界面科學與工程霍夫曼家族國際研討會最佳海報獎 (指導學生:黃湞鈺)
    2016 科技部獎勵新聘特殊優秀人才補助
    2016 國立臺灣大學優良教師
    2015 科技部獎勵新聘特殊優秀人才補助
    2014 中華民國獸醫學會學術研討會論文優等獎 (指導學生:彭茹憶)
    2013 中華民國獸醫學會學術研討會論文優等獎 (指導學生:彭茹憶)
    2011 科技部海外博士後研究獎學金
    2010 國立台灣大學生物資源暨農學院學術論文獎
    2009 中華民國獸醫學會學術研討會論文優等獎

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