張芳嘉 教授(兼任動物醫院藥劑室主任)

神經生理研究室(獸一館407R)

研究領域:神經科學、睡眠生理、睡眠醫學
擔任課程: 胚胎學、獸醫生理學、獸醫生理學實習、動物組織學、動物組織學實習、神經電氣生理學、獸醫遺傳學
聯絡電話:Office:(02)3366-3883; Lab: (02)3366-3884
電子信箱:fchang@ntu.edu.tw
學歷:高雄醫學院藥學系學士
         國立成功大學藥理學研究所碩士
         美國德州大學解剖暨神經科學博士
Office hours: 星期一8:00-12:00、星期五8:00-12:00 (請同學先以Email方式與老師約定時間)

張芳嘉老師
近期學術著作:
  • 研究計劃
    1. 利用基因轉殖鳥類研究視覺處理模式及認知行為 (2/2)
      (MOST104-2911-I-002-577; 2016.9.1 ~2017.8.31)
    2. 利用基因轉殖鳥類研究視覺處理模式及認知行為 (1/2)
      (MOST104-2911-I-002-577; 2015.9.1 ~2016.8.31)
    3. 藍光對情緒與認知的影響-子計畫二:不同的藍光照射型態對於睡眠以及睡眠節律的作用機制:電生理極光遺傳學研究
      (MOST104-2410-H-002-053; 2015.8.1 ~2016.7.31)
    4. 植入式交感神經阻斷電刺激晶片在手汗症治療之應用—動物實驗 (3/3)
      (MOST103-2321-B-002-019; 2014.8.1 ~2015.7.31)
    5. 植入式交感神經阻斷電刺激晶片在手汗症治療之應用—動物實驗 (2/3)
      (MOST102-2321-B-002-050; 2013.8.1 ~2014.7.31)
    6. 植入式交感神經阻斷電刺激晶片在手汗症治療之應用—動物實驗 (1/3)
      (MOST101-2321-B-002-065; 2012.8.1 ~2013.7.31)
    7. 國立臺灣大學『邁向頂尖大學計畫』之『促進產學合作策略聯盟計畫』-Scnla基因替換小鼠(E1099X)的特性分析及Concordant Oligos 對高體溫誘發癲癇的作用(2013.6.1 ~2013.12.31)
    8. 探討視叉上核節律週期基因在顳葉癲癇模式老鼠中所產生的節律變化 (NSC99-2320-B-002-026-MY3; 2010.8.1 ~2013.7.31)
    9. 國立臺灣大學『邁向頂尖大學計畫』之『促進產學合作策略聯盟計畫』-以Scn1a基因替換小鼠(E1099X)為Dravet Syndrome之動物模式進行試種新型藥物篩檢(2011.6.1 ~2012.5.30)
    10. 國立臺灣大學『邁向頂尖大學計畫』之『促進產學合作策略聯盟計畫』-Concordant antisense 對Scn1a基因替換小鼠(E1099X)自發性癲癇的作用(2012.6.1 ~2012.12.31)
    11. 國立臺灣大學『邁向頂尖大學計畫』之『促進產學合作策略聯盟計畫』-針對閉鎖式抗癲癇腦刺激應用之可植入式生物醫療系統單晶片平台(2010.1.1 ~2014.12.31)
    12. 國立臺灣大學『邁向頂尖大學計畫』之『促進產學合作策略聯盟計畫』-Dravet Syndrome癲癇症候群之研究:由臨床到基礎(2010.1.1 ~ 2012.12.31)
    13. 探討黃芩主成分,黃芩苷及漢黃芩素,對proteasome inhibitor所誘發的巴金森氏症的作用,對神經細胞突觸可塑性的作用,及對巴金森氏症所導致的睡眠干擾之作用—分子訊息傳遞路徑及電生理學研究 (NSC96-2628-B-002-029-MY3; 2007.8.1 ~2010.7.31)
    14. 探討endorphin與乙醯膽鹼受體在nucleus tractus solitarius中對電針安眠穴所產生之睡眠變化的相關機制: 行為學和電生理學研究 (NSC95-2320-B-002-098-MY2; 2006.8.1 ~ 2008.7.31)
    15. 在kindling誘發癲癇模式中CRH及IL-1beta對nucleus basalis of Meynert中受體誘發電流的作用 (NSC94-2320-B-002-126; 2005.8.1 ~ 2006.7.31)
    16. 以MPTP 誘發巴金森症之動物模式來探討其對睡眠的影響及相關機制(2/2) (NSC93-2314-B-039-002; 2004.8.1 ~ 2005.7.31)
  • 期刊論文

    1. Yi, P.L., Lu, C.Y., Jou, S.B., Chang, F.C.*, 2015. Low-frequency electroacupuncture suppresses focal epilepsy and improves epilepsy-induced sleep disruptions. J Biomed Sci 22, 49. (SCI)
    2. Chen, W. T., Chang, F.C., Chen, Y.J., Lin, J.G., 2014. An evaluation of electroacupuncture at the Weizhong acupoint (BL-40) as a means of relieving pain induced by extracorporeal shock wave lithotripsy. Evid Based Complement Alternat 2014, Article ID592319. (SCI)
    3. Yi, P.L., Lu, C.Y., Cheng, C.H., Tsai, Y.F., Lin, C.T., Chang, F.C.*, 2013. Amygdala opioid receptors mediate the electroacupuncture-induced deterioration of sleep disruptions in epilepsy rats. J Biomed Sci20, 85. (SCI)
    4. Yi, P.L., Lu, C.Y., Cheng, C.H., Tsai, Y.F., Lin, C.T., Chang, F.C.*, 2013. Activation of Amygdala Opioid Receptors by Electroacupuncture of Feng-Chi (GB20) Acupoints Exacerbates Focal Epilepsy. BMC Complement Altern Med 13, 290. (SCI)
    5. Hsaio, Y.T., Yi, P.L., Cheng, C.H., Chang, F.C.*, 2013. Disruption of footshock-induced theta rhythms by stimulating median raphe nucleus reduces anxiety in rats. Behav Brain Res 247, 193-200. (SCI)
    6. Jou, S.B., Kuo, I.F., Yi, P.L., Chang, F.C.*, 2013. Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats. Seizure 22, 221-229. (SCI)
    7. Hsiao, Y.T., Cheng, C.H., Yi, P.L., Chang, F.C.*, 2013. GABAergic neurons in the median raphe nucleus (MRN) modulate footshock-induced rapid eye movement (REM) sleep disturbance in rats. Taiwan Vet J 39(1), 27-38.
    8. Yi, P.L., Chen, Y.J., Lin, C.T., Chang, F.C.*, 2012. Occurrence of Epilepsy at Different Zeitgeber Times Alters Sleep Homeostasis Differently in Rats. Sleep 35(12), 1651-1665. (SCI)
    9. Hsu, C.Y., Chang, F.C.*, Ng, H.Y., Kuo, C.C., Lee, Y.T., Lu, C.Y., Lee, C.T., 2012. Disrupted circadian rhythm in rats with nephrectomy-induced chronic kidney disease. Life Sci 91, 127-131. (SCI)
    10. Hsiao, Y.T., Jou, S.B., Yi, P.L., Chang, F.C.*, 2012. Activation of GABAergic pathway by hypocretin in the median raphe nucleus (MRN) mediates stress-induced theta rhythm in rats. Behav Brain Res233, 224-231. (SCI)
    11. Cheng, C.H., Yi, P.L., Chang, H.H., Chang, F.C.*, 2012. Morphology Alterations of Synapses in the Ventromedial Nucleus (VM) of Thalamus and Caudal Nucleus Tractus Solitarius (NTS) after 10 Hz Electroacupuncture in Rats. Taiwan Vet J38(2), 75-83.
    12. Hsiao, Y.T., Yi, P.L., Li, C.L., Chang, F.C.*, 2012. Effect of Cannabidiol on Sleep Disruption Induced by the Repeated Combination Tests consisting of Open Field and Elevated Plus-maze in Rats. Neuropharmacology 62, 373-384. (SCI)
    13. Cheng, C.H., Yi, P.L., Chang, H.H., Tsai, Y.F., Chang, F.C.*, 2012. Kappa-opioid Receptors in the Caudal Nucleus Tractus Solitarius (NTS) Mediate 100 Hz Electroacupuncture-induced Sleep Activities in Rats. Evid Based Complement Alternat 2012, Article ID715024. (SCI)
    14. Chang, F.C.*, 2011. Effects of traditional Chinese medicine in insomnia treatment: the possible physiological mechanisms. In: Leon V. Berhardt, editor. Advances in Medicine and Biology: Volume 22. Nova Science Publishers:New York, Chapter 3.
    15. Chang, H.H., Yi, P.L., Cheng, C.H., Lu, C.Y., Hsiao, Y.T., Tsai, Y.F., Li, C.L., Chang, F.C.*, 2011. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol 135, 359-368. (SCI)
    16. Cheng, C.H., Yi, P.L., Lin, J.G., Chang, F.C.*, 2011. Endogenous opiates in the nucleus tractus solitaries mediate electroacupuncture-induced sleep activities in rats. Evid Based Complement Alternat 2011, Article ID159209. (SCI)
    17. Cheng, C.H., Ku, Y.F., Hou, C.H., Yeh, L.S., Chang, F.C.*, 2011. Nerve re-innervations by an end-to-side neurorrhaphy of myocutaneous transplantation in rats. Taiwan Vet J 37(3), 143-151.
    18. Chang, H.H., Cheng, C.H., Yi, P.L., Lu, C.Y., Tsai, Y.F., Hsiao, Y.T., Chang, F.C.*, 2011. Biphasic Effects of Wogonin in the Regulation of Spontaneous Sleep. Taiwan Vet J37 (3), 180-190.
    19. Chen, J.H., Jan, T.R., Chang, F.C., Chou, C.C., 2011. Metabolism, neurotoxicity, and food safety influences of acrylamide. Taiwan Vet J37(1), 63-73.
    20. Lu, C.Y., Yi, P.L., Tsai, C.H., Cheng, C.H., Chang, H.H., Hsiao, Y.T., Chang, F.C.*, 2010. TNF-NF-kappa B signaling mediates excessive somnolence in hemiparkinsonian rats. Behav Brain Res 208, 484-496. (SCI)
    21. Chang, F.C.*, 2009. Minireview: canine insomnia. J Vet Clin Sci2(4), 100-107.
    22. Wey, S.P., Wu, H.Y., Chang, F.C., Jan, T.R., 2008. Methamphetamine and diazepam suppress antigen-specific cytokine expression and antibody production in ovalbumin-sensitized BALB/c mice. Toxicol Lett 181, 157-162. (SCI)
    23. Yi, P.L., Hsiao, Y.T., Tsai, C.H., Jan, T.R., Lu, C.Y., Chang, F.C.*. Serotonergic system in the central nucleus of amygdala mediates cannabidiol-induced sleep alteration. The Open Sleep J 1, 58-68.
    24. Lu, M,K., Shih, H.Z., Huang, K.J., Ziemann, U., Tsai, C.H., Chang, F.C.*, Chen, Y.C., Lin, Y.T., Huang, W.S., Lee, C.C., Liu, C.S., 2008. Movement-Related Cortical Potential in Patients with Machado-Joseph Disease. Clin Neurophysiol 119, 1010-1019. (SCI)
    25. Yi, P.L., Lin, C.P., Tsai, C.H., Lin, J.G., Chang, F.C.*, 2007. The involvement of serotonin receptors in suanzaorentang-induced sleep alteration. J Biomed Sci 14, 829-840. (SCI)
    26. Yi, P.L., Tsai, C.H., Lu, M.K., Liu, H.J., Chen, Y.C., Chang, F.C.*, 2007. Interleukin-1beta mediates sleep alteration in rats with rotenone-induced parkinsonism. Sleep 30(4), 413-425. (SCI)
    27. Yi, P.L., Tsai, C.H., Chen, Y.C., Chang, F.C.*, 2007. Gamma-aminobutyric acid (GABA) receptor mediates suanzaorentang, a traditional Chinese herb remedy, -induced sleep alteration. J Biomed Sci 14, 258-297. (SCI)
    28. Lu, M.K., Chang, F.C., Yang, Y.W., Lin, Y.C., Lee, C.C., Tsai, C.H., 2006. Abnormal movement-related cortical potential in patients with subcortical heterotopia. Brain Develop 28, 560-565. (SCI)
    29. Yang, Y.W., Tsai, C.H., Chang, F.C., Lu, M.K., Chiu, P., 2006. Reversible Paraneoplastic Limbic Encephalitis Caused by a Benign Ovarian Teratoma: Report of a Case and Review of literatures. J Neuro-Oncol 80, 309-312. (SCI)
    30. Tsai, C.H., Chang, F.C., Huang, Y.T, Chen, R.S., Chen, C.C., Wu, T., Weng, Y.H., Lee, S.Z., Lee, Z.D., Lieu, C.Y., Chang, H.C., Lu, M.K., Lee, C.C., Lu, C.S., 2005. Pallidotomy effect on the central excitability in patients with severe Parkinson’s disease. Movement Disord 20(4), 463-470. (SCI)
    31. Yang, Y.W., Chang, F.C., Tsai, C.H., Wu, J.C., Lu, C.S., Kuo, C.C., Lu, M.K., Chen, W.L., Lee, C.C., 2005. Clinical and magnetic resonance imaging manifestations of Holmes Tremor. Acta Neurol Taiwan 14(1), 9-15. (SCI)
    32. Yi, P.L., Tsai, C.H., Lin, J.G., Liu, H.J., Chang, F.C.*, 2004. Effects of electroacupuncture of “Anmian” acupoints on sleep activities in rats: the implication of caudal nucleus tractus solitarius.J Biomed Sci 11, 579-590. (SCI)
    33. Yi, P.L., Tsai, C.H., Lu, M.K., Chen, Y.J., Yang, Y.W., Chang, F.C.*, 2004. The Effects of a Brief Light Pulse and Intracerebroventricular Injection on Sleep-Wake Activity in Rats. Mid-Taiwan J Med9(4), 211-218.
    34. Yi, P.L., Opp, M.R., Chang, F.C.*, 2004. Increase of corticotropin-releasing hormone (CRH) in the central nervous system mediates stressors-induced sleep alteration. Mid-Taiwan J Med 9(3), 80-86.
    35. Yi, P.L., Tsai, C.H., Lin, J.G., Lee, C.C., Chang, F.C.*, 2004. Kindling stimuli delivered at different times in the sleep-wake cycle. Sleep 27(2), 203-212. (SCI)
    36. Chang, F.C., Tsai, H.Y., Yu, M.C., Yi, P.L., Lin, J.G., 2004. Central serotonergic system mediates analgesic effect of electroacupuncture on Zusanli (ST36) acupoint. J Biomed Sci 11, 179-185. (SCI)
    37. Tsai, C.H., Chang, F.C, Su, Y.C., Tsai, F.J., Lu, M.K., Lee, C.C., Kuo, C.C., Yang, Y.W., Lu, C.S., 2004. Two novel mutations of the glycine receptor gene and electrophysiological manifestation in a family with autosomal recessive hereditary hypereklpexia. Neurology 63(5), 893-896. (SCI)
    38. Chang, F.C., Opp, M.R., 2004. A corticotropin-releasing hormone antisense oligodeoxynucleotide reduces spontaneous waking in the rats. Regul Pept  117(1), 43-52. (SCI)
    39. Tsai, P.C., Chang, F.C., Tsai, C.H., Jang, F.R., Shen, A.N., Huang, Y.T., Lai, S.C., Yeh, T.H., Lu, M.K., Lu, C.S., 2003. Focal hand myoclonus caused by a small hematoma underneath the cerebral motor cortex. Eur Neurol 50, 114-117. (SCI)
    40. Tsai, T.C., Wu, J.Y., Lee, C.C., Tsai, C.H., Tsai, F.J., Chang, F.C., Kuo, C.C., 2003. No association between the dopamine transproter gene polymorphism and sporadic Parkinson’s disease among Chinese in Taiwan.  Mid-Taiwan J Med 8(Suppl 2), S75-8.
    41. Chang, F.C., Opp, M.R., 2002. The role of corticotropin-releasing hormone (CRH) in stressor-induced alterations of sleep in the rat. Am J Physiol Regul Integr Comp Physiol 283, R400-R407. (SCI)
    42. Tsai, C.H., Lo, S.K., See, L.C., Chen, H.Z., Chen, R.S., Weng, Y.H., Chang, F.C., Lu, C.S., 2002. Environmental risk factors of young onset Parkinson’s disease: a case-control study. Clin Neurol Neurosurg 104, 328-333. (SCI)
    43. Chang, F.C.*, Opp, M.R., 2001. Corticotropin-releasing hormone (CRH) as a regulator of waking, Neurosci Biobehav Rev 25(5), 445-453. (SCI)
    44. Chang, F.C., Opp, M.R., 2000. IL-1 is a mediator of increases in slow wave sleep induced by CRH receptor blockade. Am J Physiol Regul Integr Comp Physiol 279, R793-R802. (SCI)
    45. Chang, F.C., Opp, M.R., 1999. Pituitary CRH receptor blockade reduces waking in the rat. Physiol Behav 67, 691-696. (SCI)
    46. Chang, F.C., Opp, M.R., 1998. Blockade of corticotropin-releasing hormone (CRH) receptors reduces spontaneous waking in the rat. Am J Physiol Regul Integr Comp Physiol 275, R793-R802. (SCI)
    47. Yi, P.L., Chang, F.C., Tsai, J.J., Hung, C.R., Gean, P.W., 1995. The involvement of metabotropic glutamate receptors in long-term depression of N-methyl-D-aspartate receptor-mediated synaptic potential in the rat hippocampus. Neurosci Lett 185, 207-210. (SCI)
    48. Gean, P.W., Chang, F.C., Yi, P.L., Lin, J.H., Tsai, J.J., 1995. Activation of metabotropic glutamate receptors in conjunction with postsynaptic depolarization triggers a long-term depression of the N-methyl-D-aspartate receptor-mediated synaptic potential in the rat hippocampus. J Biomed Sci 2, 166-173. (SCI)
    49. Gean, P.W., Chang, F.C., Huang, C.C., Lin, J.H., Way, L.J., 1993. Long-term enhancement of EPSP and NMDA receptor-mediated synaptic transmission in the amygdala. Brain Res Bull 31, 7-11. (SCI)
    50. Gean, P.W., Chang, F.C., Huang, C.R., 1993. Use-dependent modification of a slow NMDA receptor-mediated synaptic potential in rat amygdalar slices. J Neurosci Res 34, 635-641. (SCI)
    51. Gean, P.W., Chang, F.C., 1992. Pharmacological characterization of excitatory synaptic potentials in rat basolateral amygdaloid neurons. Synapse 11, 1-9. (SCI)
    52. Gean, P.W., Chang, F.C., 1991. Ketamine suppresses synchronized discharges in the disinhibited amygdala slice. Brain Res Bull 26, 923-927. (SCI)
    53. Gean, P.W., Chang, F.C., 1991. Bursting discharges in disinhibited amygdala slices: the role of excitatory amino acid receptors. Neuropharmacology 30, 797-803. (SCI)
    54. Gean, P.W., Chou, S.M., Chang, F.C., 1990. Epileptiform activity involved by 4-aminopyridine in rat amygdala neurons: the involvement of N-methyl-D-aspartate receptors. Eur J Pharmacol 184, 213-221. (SCI)

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